fromwww.nature.com
4 days agoCancer
Polyclonal origins of human premalignant colorectal lesions
Early colorectal cancers may arise from multiple genetically distinct founding cell populations rather than expansion of a single mutant cell.
The camera is not a radical departure from the physical design of last year's model, but DJI is introducing some innovative new functionality. For example, it features an adjustable aperture that uses a mechanical iris (rather than relying on software tricks) and a larger square format sensor that offers more flexibility when you want to crop footage to various horizontal and vertical aspect ratios.
Business Insider has spent a year reporting on the true cost of a cancer diagnosis for young Americans. Cancer cases are rising for people in their 20s, 30s, and 40s, derailing finances and future plans at a pivotal stage of life. Dozens of patients have told us they're navigating relationships, fertility decisions, early parenthood, and career growth alongside treatment. They're paying medical bills and for all the unexpected costs along the way.
Blocking the mechanism that cancer cells exploit to avoid destruction by the immune system could spur new treatments for the disease. Researchers have developed an antibody that prevents pancreatic cancer cells from evading the immune system and slows tumour growth. The discovery could lead to more treatment options for pancreatic ductal adenocarcinoma - the most common type of pancreatic cancer, which has limited treatment options and a low survival rate.
Northwestern Medicine scientists have discovered how a specific transcription factor promotes genetic reprogramming and chemotherapy resistance in ovarian cancer cells, findings that may inform new targeted treatment approaches that inhibit this process and improve patient outcomes, according to a recent study published in The Journal of Clinical Investigation. Mazhar Adli, PhD, the Thomas J. Watkins Memorial Professor of Tumor Genomics, was senior author of the study.
Parity and breastfeeding reduce the risk of breast cancer, particularly triple-negative breast cancer (TNBC)1,2, yet the immunological mechanisms underlying this protection remain unclear. Here, we show that parity induces an accumulation of CD8+ T cells, including cells with a tissue-resident memory (TRM)-like phenotype within human normal breast tissue. In murine models, pregnancy followed by lactation and involution drove the accumulation of CD8 T
As detailed in a new paper published in the journal Cell Reports Medicine, the shot works by encasing adjuvants, which substances that increase or modulate the immune response to a vaccine, and melanoma peptide antigens, short amino acid sequences that can be recognized by the body, inside specialized lipid nanoparticles. In one experiment, the team found that 80 percent of vaccinated mice that had been exposed to melanoma cells three weeks earlier remained tumor-free for 250 days, the full duration of the study.
From reproductive rights to climate change to Big Tech, The Independent is on the ground when the story is developing. Whether it's investigating the financials of Elon Musk's pro-Trump PAC or producing our latest documentary, 'The A Word', which shines a light on the American women fighting for reproductive rights, we know how important it is to parse out the facts from the messaging.
CINCINNATI -- Cincinnati Bengals coach Zac Taylor did not have an official timeline for quarterback Joe Burrow to return following successful toe surgery on Friday. Burrow underwent surgery to repair a turf toe injury on his left foot, Taylor said after Friday's practice. The coach said the surgery went well. "There's no reason to give a timeline," Taylor said. "We don't have a timeline. Now he's just in recovery and we'll go from there."
Towards the end of 2019, Becca Smith's life was full and hectic. At 28, she had taken on a unit in Chester to convert into a yoga studio, poured in all her savings and hired teachers, while at the same time working as a personal trainer. Her days started at 5am; she was driven, stressed, excited, and had no time for the back pain that just would not subside.
By the grace of G-d, my daughter survived breast cancer. The woman who used to practice yoga, jog, and not keep red meat or chips in the house, is now drinking a glass of wine more nights than not and spending her days off binging shows and movies. Her logic is, she was healthy before and still developed cancer, why not indulge?
Keeping a friend group together long-term is no easy task. As people get older, move away, change jobs, or go back to school, it makes it tougher to maintain a connection - and just like that, you all lose touch. While it's natural for some friendships to fade away over time, certain members of the zodiac aren't going to stand back and watch it happen for no reason. In fact,