Parity and breastfeeding reduce the risk of breast cancer, particularly triple-negative breast cancer (TNBC)1,2, yet the immunological mechanisms underlying this protection remain unclear. Here, we show that parity induces an accumulation of CD8+ T cells, including cells with a tissue-resident memory (TRM)-like phenotype within human normal breast tissue. In murine models, pregnancy followed by lactation and involution drove the accumulation of CD8 T
As detailed in a new paper published in the journal Cell Reports Medicine, the shot works by encasing adjuvants, which substances that increase or modulate the immune response to a vaccine, and melanoma peptide antigens, short amino acid sequences that can be recognized by the body, inside specialized lipid nanoparticles. In one experiment, the team found that 80 percent of vaccinated mice that had been exposed to melanoma cells three weeks earlier remained tumor-free for 250 days, the full duration of the study.
From reproductive rights to climate change to Big Tech, The Independent is on the ground when the story is developing. Whether it's investigating the financials of Elon Musk's pro-Trump PAC or producing our latest documentary, 'The A Word', which shines a light on the American women fighting for reproductive rights, we know how important it is to parse out the facts from the messaging.
CINCINNATI -- Cincinnati Bengals coach Zac Taylor did not have an official timeline for quarterback Joe Burrow to return following successful toe surgery on Friday. Burrow underwent surgery to repair a turf toe injury on his left foot, Taylor said after Friday's practice. The coach said the surgery went well. "There's no reason to give a timeline," Taylor said. "We don't have a timeline. Now he's just in recovery and we'll go from there."
Towards the end of 2019, Becca Smith's life was full and hectic. At 28, she had taken on a unit in Chester to convert into a yoga studio, poured in all her savings and hired teachers, while at the same time working as a personal trainer. Her days started at 5am; she was driven, stressed, excited, and had no time for the back pain that just would not subside.
By the grace of G-d, my daughter survived breast cancer. The woman who used to practice yoga, jog, and not keep red meat or chips in the house, is now drinking a glass of wine more nights than not and spending her days off binging shows and movies. Her logic is, she was healthy before and still developed cancer, why not indulge?
Keeping a friend group together long-term is no easy task. As people get older, move away, change jobs, or go back to school, it makes it tougher to maintain a connection - and just like that, you all lose touch. While it's natural for some friendships to fade away over time, certain members of the zodiac aren't going to stand back and watch it happen for no reason. In fact,
"B-cells, which are responsible for producing antibodies, rely on BCRs for survival and growth. While most research has focused on the IgM variant of BCRs, this study sheds light on the lesser-understood IgG1 variant," said Vipul Shukla, PhD, assistant professor of Cell and Developmental Biology, who was co-senior author of the study. "Our lab focuses on understanding the molecular control of B-cell function, which are a key component of the immune system responsible for generating antibodies,"
In a wholly new approach to cancer treatment, Northwestern University biomedical engineers have doubled the effectiveness of chemotherapy in animal experiments. Instead of attacking cancer directly, the first-of-its-kind strategy prevents cancer cells from evolving to withstand treatment - making the disease easier to target with existing drugs. Not only did the approach fully wipe out the disease to near completion in cellular cultures, but it also dramatically increased the effectiveness of chemotherapy in mouse models of human ovarian cancer.
The ability of cancer cells to adopt new phenotypes without further DNA mutations is now well understood to substantially influence tumour behaviour. Such plasticity has long been observed in melanoma, where early studies identified transcriptomic and phenotypic states not linked to specific genetic lesions1. More recent evidence indicates that most tumours encompass a heterogeneous yet reproducible number of transcriptional states3,4. The extent to which tumour cells transition between states is an open area of investigation and has been hypothesized to be regulated by cues from the tumour microenvironment (TME).
Megan Royal paid tribute to her mother during the funeral service, highlighting her bright, colorful, creative personality and how she had learned so much from her.
