Cancer

Cancer

DNA repair deficiency, intrinsic genomic instability and an immunogenic tumour microenvironment make TNBC an interesting candidate for individualized vaccination with somatic cancer mutations that can act as neoantigens2,3. We developed an individualized neoantigen RNA vaccine approach that uses next generation sequencing (NGS) for mutation calling and predicts potentially T cell immunity-inducing neoantigens. This approach is being studied in patients with melanoma and pancreatic and other solid cancers4,5,6,7 (Extended Data Fig. 1a).

Scientists in the laboratory of Rendong Yang, PhD, associate professor of Urology, have developed a new large language model that can interpret transcriptomic data in cancer cell lines more accurately than conventional approaches, as detailed in a recent study published in Nature Communications. Long-read RNA sequencing technologies have transformed transcriptomics research by detecting complex RNA splicing and gene fusion events that have often been missed by conventional short-read RNA-sequencing methods.

Although specific bacterial taxa have been associated with favourable clinical responses to immune checkpoint blockade (ICB) in cancer patients12,13,18,19,20,21,22, the mechanisms by which the intestinal microbiota influences anti-tumour immune responses remain poorly defined. Products of the microbiota, including metabolites23,24,25 and innate receptor ligands26, may reprogramme myeloid cells27, lowering the activation threshold for antigen presentation and thereby facilitating priming and activation of tumour-reactive T cells.

Just 10 minutes of intense exercise can flip genetic switches that help stop bowel cancer in its tracks. Credit: Shutterstock As people return to gyms or start new fitness routines in the new year, new research suggests that even a short burst of intense exercise could play a role in protecting against cancer. Scientists report that as little as 10 minutes of hard physical activity may help slow cancer growth.

For more than six months, I was living with a strange kind of persistent, stabbing pain that would return again and again through the course of the day. It didn't seem to matter if I popped a Tums or changed what I ate. It's hard to put food down when it feels like you're being consistently pummeled from the inside. The pain got so bad that I was subsisting on a diet of little more than chocolate milk and mixed fruit from the dining hall.

King Charles is set to share a personal cancer update tonight in a video message during Stand Up To Cancer programmes on Channel 4. The King's message will be broadcast on Friday (12 December) as a part of a joint campaign by Cancer Research UK and Channel 4. It will emphasise the vitalness of cancer screening programmes, which can help detect and get an early diagnosis. The message was recorded during the last week of November in Clarence House's morning room.

Then she asked a childhood friend, Ping Chong, to hold onto her records, including the death certificate of her husband, who had died of cancer three years earlier. Chong, reluctant to confront the prospect of her dear friend's death, refused at first. But Hang, who never shouted, pounded the table with a fist weakened by chemotherapy and yelled at Chong to take her request seriously.