Chronic inflammation is a central driver of pathological fibrosis after ischaemic or haemodynamic stress, but strategies that locally rebalance injurious and reparative immune responses without systemic immunosuppression are lacking.
I went to ChatGPT and came up with a plan on how to do this. He also used AlphaFold, an AI tool from Google's DeepMind, to find mutated proteins that could be potential targets for treatment. While an immunotherapy treatment that looked like a good fit for Rosie was identified, the drugmaker wouldn't provide it.
Anais Muczynski, 36, an orthoptist who lives with her husband Vincent Muczynski, 41, a researcher, received her primary breast cancer diagnosis in January 2023 after discovering a quail egg-sized lump in her left breast. At the time, the London-based couple were "optimistic", as it was stage one meaning the cancer was only in the breast tissue or in the lymph nodes close to the breast and she underwent chemotherapy, immunotherapy, and a double mastectomy.
Researchers gave 10 people with HIV a complex regimen of experimental immunotherapies, then discontinued the daily pills that kept the virus at bay. In six participants, the virus rebounded slowly and stayed at a low level for months, and one person's immune system kept the virus in check for more than a year and a half - giving scientists hope that they could optimize the approach to create a cure.
The class of immune cells at the centre of Monday's Nobel prize is showing promise as a treatment for autoimmune diseases, cancer and even organ transplants - but there are still key challenges to overcome before these cells can be used in therapies in the clinic. Regulatory T cells, or T reg cells, help to prevent the body from attacking its own tissues.
Scientists in the laboratory of Weiguo Cui, PhD, professor of Pathology in the Division of Experimental Pathology, have identified novel molecular mechanisms that help specialized T-cells maintain long-term immunity in response to chronic infection and cancer, according to recent findings published in Nature Immunology. Previous work from Cui's laboratory and others revealed that exhausted T-cells, or T-cells that have become dysfunctional after chronic antigen stimulation such as chronic infection and cancer, comprise different subgroups of T-cells.
