Medicine
fromNature
11 hours agoPersonalized CRISPR therapies could soon reach thousands - here's how
FDA proposed a 'plausible mechanism pathway' to enhance development of personalized genetic therapies for rare disorders.
More than 30,000 hectares of land are covered in plastic, a geometric labyrinth five times the size of Manhattan, where 3.5m tons of vegetables are produced every year from tomatoes to cucumbers, peppers to courgettes, aubergines to melons, enough to feed half a billion people and generate a turnover of more than 3bn euros.
If we did that today, it would be a hundred percent, because right now, without question, 2026 is riskier than 2025. So farmers really [face significant challenges]. The war in Iran continues and it works back to the world of agriculture. It's had an impact on fertiliser and diesel prices and commodity markets, as well as currency.
Scientists in the laboratory of Rendong Yang, PhD, associate professor of Urology, have developed a new large language model that can interpret transcriptomic data in cancer cell lines more accurately than conventional approaches, as detailed in a recent study published in Nature Communications. Long-read RNA sequencing technologies have transformed transcriptomics research by detecting complex RNA splicing and gene fusion events that have often been missed by conventional short-read RNA-sequencing methods.
Biology is undergoing a transformation. After centuries of studying life as it evolves naturally, researchers are now using a combination of computation and genome engineering to intervene, generating new proteins and even whole bacteria from scratch. The use of artificial-intelligence tools to design biological components, an approach known as generative biology, is set to turbocharge this area of research. Just last year, scientists used AI-assisted design to produce artificial genes that can be expressed in mammalian cells.
Yaghi describes AI not as a silver bullet, but as an advanced form of statistical pattern recognition-tools that can identify trends in data that may be difficult or time-consuming for people to uncover on their own. The real opportunity, he says, depends heavily on what farms are already doing. Operations that are consistently collecting and digitizing high-quality data are better positioned to benefit, whether the goal is lowering per-cow costs in a dairy, improving financial analysis, or identifying operational efficiencies.
Martschenko's argument is largely that genetic research and data have almost always been used thus far as a justification to further entrench extant social inequalities. But we know the solutions to many of the injustices in our world-trying to lift people out of poverty, for example-and we certainly don't need more genetic research to implement them. Trejo's point is largely that more information is generally better than less.
About ten years ago researchers across a wide range of disciplines, from forensic science and genetics to art history, got together with the goal of finding the Renaissance artist's DNA. Da Vinci had no children, and his remains were disturbed during the French Revolution. The hope is that uncovering his DNA could open the door to a number of discoveries, including new tools for authenticating artwork and potential clues about da Vinci's uncanny way of seeing the world.