Spatial transcriptomic clocks reveal cell proximity effects in brain ageing - NatureHigh-throughput spatial omics aids in understanding the spatial interactions in brain ageing, crucial for tackling neurodegenerative diseases.
Which disease-modifying Alzheimer's drugs are the most promising?The UK health watchdog has rejected two new Alzheimer's drugs due to concerns over their effectiveness and potential side effects.
Author Correction: Microglia-mediated T cell infiltration drives neurodegeneration in tauopathyCorrection does not affect interpretation of the data on T cell infiltration in tauopathy.
CryoET of -amyloid and tau within postmortem Alzheimer's disease brain - NatureAlzheimer's disease is characterized by the accumulation of aggregated Aβ peptides and tau, with mutations in genes like APP and PSEN leading to familial cases.
Which disease-modifying Alzheimer's drugs are the most promising?The UK health watchdog has rejected two new Alzheimer's drugs due to concerns over their effectiveness and potential side effects.
Author Correction: Microglia-mediated T cell infiltration drives neurodegeneration in tauopathyCorrection does not affect interpretation of the data on T cell infiltration in tauopathy.
CryoET of -amyloid and tau within postmortem Alzheimer's disease brain - NatureAlzheimer's disease is characterized by the accumulation of aggregated Aβ peptides and tau, with mutations in genes like APP and PSEN leading to familial cases.
Does air pollution cause dementia? UK scientists launch study to find outAir pollution significantly affects brain health and is linked to dementia, prompting new research to explore this connection.
Parkinson's may take a 'gut-first' path - Harvard GazetteUpper GI lining damage significantly increases the risk of developing Parkinson's disease, emphasizing potential 'gut-first' pathways for intervention.
Can Better Biotech Finally Replace Lab Animals?Itzy Morales Pantoja transitioned from animal testing to developing lab-grown models to advance neurodegeneration research and reduce reliance on animal studies.