Mitochondrial dysfunction plays a crucial role in neurodegeneration, with a significant 42% of adults over age 55 expected to develop dementia by 95. The energy demands of brain cells are immense, with each cortical neuron requiring 4.7 billion ATP molecules every second. The loss of mitochondrial efficiency results in cellular stress and damage, particularly affecting brain cells. Strategies to maintain mitochondrial health include dietary adjustments and reducing exposure to toxins, which may help mitigate cognitive decline associated with aging and dementia.
When mitochondria lose their efficient shape, electrons escape and form reactive oxygen species, triggering cellular damage and stress that particularly affects brain cells.
Research shows 42% of adults over 55 develop dementia by age 95, with projected new cases expected to double from 514,000 in 2020 to 1 million by 2060.
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