In the originally published version of this article, Extended Data Fig. 4 contained inadvertent duplications introduced during figure assembly: panel 4c (the bottom of the second column) erroneously reused images from panel 4a (the bottom of the third column); panel 4c (the upper panel of the third column) erroneously reused images from panel 4a (the upper panel of the rightmost column);
In terms of making things happen, energy is an indispensable consideration. Systems spontaneously tend towards the lowest-energy state. When a system reaches equilibrium, no further energy can be extracted. That maximum entropy, lowest energy state is the inevitable end-state of the Universe. But until that moment arrives, reactions of all kinds will occur, continuing to liberate energy. In our bodies, chemical bonds break and reform: releasing energy.