The study found that Alzheimer's disease progresses in two distinct phases: a slow early phase followed by an exponential worsening, primarily impacting somatostatin inhibitory neurons.
Ed Lein mentions, 'This was quite a surprise because these neurons have received relatively little attention from Alzheimer's researchers, indicating a gap in the understanding of the disease.'
The results indicate that Alzheimer's treatments may be most effective when administered early in the disease, particularly focusing on protecting vulnerable somatostatin neurons.
Dr. Richard Hodes highlights that, 'New tools and techniques are redefining our understanding of Alzheimer's, bringing insights that were unimaginable just a few years ago.'
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