#cell-biology

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#cancer-research

'Dark proteins' hiding in our cells could hold clues to cancer and other diseases

Ribosome profiling revealed the existence of 'dark proteins' produced from previously unknown genomic regions.

7 Big Questions About Cancer, Answered

Cancer development is influenced by both genetic mutations and epigenetic changes, highlighting the complexity of treatment and understanding.

Goyal and Kennedy Named 2024 Pew Scholars - News Center

Feinberg faculty members named 2024 Pew Scholars, accelerating biomedical sciences.

What is a cell type, really? The quest to categorize life's myriad forms

Cellular individuality complicates research, as each cell exhibits unique characteristics which may influence drug resistance in cancer treatment.

Daily briefing: Variant of mpox virus is getting better at human-to-human transmission

Semaglutide significantly alleviates obesity-related knee arthritis pain, matching the efficacy of painkillers.
Advanced mapping of tumor cells offers crucial insights for cancer treatment development.
New findings on protocell structures may shed light on the evolution of cell membranes.

Author Correction: Life-cycle-coupled evolution of mitosis in close relatives of animals - Nature

Collaboration among international researchers is crucial for addressing complex scientific challenges in cell biology and cancer research.

'Dark proteins' hiding in our cells could hold clues to cancer and other diseases

Ribosome profiling revealed the existence of 'dark proteins' produced from previously unknown genomic regions.

7 Big Questions About Cancer, Answered

Cancer development is influenced by both genetic mutations and epigenetic changes, highlighting the complexity of treatment and understanding.

Goyal and Kennedy Named 2024 Pew Scholars - News Center

Feinberg faculty members named 2024 Pew Scholars, accelerating biomedical sciences.

What is a cell type, really? The quest to categorize life's myriad forms

Cellular individuality complicates research, as each cell exhibits unique characteristics which may influence drug resistance in cancer treatment.

Daily briefing: Variant of mpox virus is getting better at human-to-human transmission

Semaglutide significantly alleviates obesity-related knee arthritis pain, matching the efficacy of painkillers.
Advanced mapping of tumor cells offers crucial insights for cancer treatment development.
New findings on protocell structures may shed light on the evolution of cell membranes.

Author Correction: Life-cycle-coupled evolution of mitosis in close relatives of animals - Nature

Collaboration among international researchers is crucial for addressing complex scientific challenges in cell biology and cancer research.
morecancer-research

Retraction Note: A mechanism for the suppression of homologous recombination in G1 cells

The study was retracted due to serious data and image irregularities.
#evolution

Scientists Recreate the Conditions That Sparked Complex Life

Researchers successfully induced endosymbiosis in the lab for the first time, shedding light on this pivotal evolutionary process.

Rain may have helped form the first cells, kick-starting life as we know it

Rainwater played a crucial role in stabilizing early cells, facilitating the evolution of complex life.

Plants' Photosynthetic Machinery Functions inside Hamster Cells

Researchers successfully implanted algae-derived chloroplasts into hamster cells, allowing them to convert light into energy for at least two days.

Evolution of a novel adrenal cell type that promotes parental care - Nature

The emergence of a novel cell type in the adrenal gland of oldfield mice contributes to the evolution of monogamous-typical parental behaviors.

Scientists Recreate the Conditions That Sparked Complex Life

Researchers successfully induced endosymbiosis in the lab for the first time, shedding light on this pivotal evolutionary process.

Rain may have helped form the first cells, kick-starting life as we know it

Rainwater played a crucial role in stabilizing early cells, facilitating the evolution of complex life.

Plants' Photosynthetic Machinery Functions inside Hamster Cells

Researchers successfully implanted algae-derived chloroplasts into hamster cells, allowing them to convert light into energy for at least two days.

Evolution of a novel adrenal cell type that promotes parental care - Nature

The emergence of a novel cell type in the adrenal gland of oldfield mice contributes to the evolution of monogamous-typical parental behaviors.
moreevolution

Contributors to Scientific American's February 2025 Issue

Mark Ross creatively illustrates complex scientific concepts, including cell biology, rooted in his artistic background.

Mysterious Blobs in Cells Are Changing the Way We Understand Life

Biomolecular condensates are crucial for cellular organization, challenging established views on cell biology.

Can Generative AI Uncover the 'Language of Biology'?

Generative AI has the potential to revolutionize our understanding of human cells by analyzing complex biological data for predictive insights.

Revealed: the fatty cells that are the 'bubble wrap' of the body

The discovery of 'lipocartilage' cells enhances the understanding of cartilage elasticity and structural support.
#metabolism

Scientists Studying Aging Are Finally Zeroing In On What Actually Triggers Age-Related Diseases

Aging is a natural process linked to metabolic decline and increased disease risk, emphasizing the need for a deeper understanding of their connection.

RANK drives structured intestinal epithelial expansion during pregnancy - Nature

Pregnancy significantly alters metabolic and cellular functions to support the health of mothers and offspring, but key mechanisms remain inadequately understood.

Scientists Studying Aging Are Finally Zeroing In On What Actually Triggers Age-Related Diseases

Aging is a natural process linked to metabolic decline and increased disease risk, emphasizing the need for a deeper understanding of their connection.

RANK drives structured intestinal epithelial expansion during pregnancy - Nature

Pregnancy significantly alters metabolic and cellular functions to support the health of mothers and offspring, but key mechanisms remain inadequately understood.
moremetabolism
#developmental-biology

DNA Typewriters' Can Record a Cell's History

Engineered cells can create genetic records, allowing scientists to track their development and changes over time.

The Human Cell Atlas from a cell census to a unified foundation model

Cell atlases leverage AI and new methods to reveal critical biological insights and are transforming our understanding of biology and medicine.

DNA Typewriters' Can Record a Cell's History

Engineered cells can create genetic records, allowing scientists to track their development and changes over time.

The Human Cell Atlas from a cell census to a unified foundation model

Cell atlases leverage AI and new methods to reveal critical biological insights and are transforming our understanding of biology and medicine.
moredevelopmental-biology

'Major milestone' as scientists map all human body cells - and the breakthrough will help target diseases

A comprehensive human cell map will enhance disease treatment and research, impacting conditions like cancer, diabetes, and arthritis.

Researchers Give Animal Cells the Ability to Photosynthesize for the First Time

A Japanese research team successfully transplanted active chloroplasts into animal cells, demonstrating functional photosynthesis and challenging previous assumptions about cell compatibility.
#alzheimers-disease

Alzheimer's timeline shows changes start as trickle, become torrent

Alzheimer's disease has two distinct phases, indicating a slow onset followed by rapid deterioration, with vulnerable neurons identified for potential early treatment.

Alzheimer's timeline shows changes start as trickle, become torrent

Alzheimer's disease has two phases, with somatostatin neurons being particularly vulnerable in the early phase.

Alzheimer's timeline shows changes start as trickle, become torrent

Alzheimer's disease has two distinct phases, indicating a slow onset followed by rapid deterioration, with vulnerable neurons identified for potential early treatment.

Alzheimer's timeline shows changes start as trickle, become torrent

Alzheimer's disease has two phases, with somatostatin neurons being particularly vulnerable in the early phase.
morealzheimers-disease
#dna

Researchers create first map of the spliceosome, an Achilles heel of cancer

Cells utilize the same DNA across types, but spliceosome machinery specifies which genes are expressed, creating diverse cell functions.

The fusion of two sisters into a single woman suggests that human identity is not in our DNA

The case of Karen Keegan, a chimeric woman, challenges the perception of DNA defining individual identity.

Researchers create first map of the spliceosome, an Achilles heel of cancer

Cells utilize the same DNA across types, but spliceosome machinery specifies which genes are expressed, creating diverse cell functions.

The fusion of two sisters into a single woman suggests that human identity is not in our DNA

The case of Karen Keegan, a chimeric woman, challenges the perception of DNA defining individual identity.
moredna
#protein-interactions

Red light, green light: flickering fluorophores reveal biochemistry in cells

Understanding protein interactions in live cells is revolutionizing our knowledge of cellular behavior.
The PAPA-fSMT method allows detailed study of protein complex dynamics during gene transcription.

'Phenomenal' tool sequences DNA and tracks proteins - without cracking cells open

The new microscopy technique enables imaging of proteins and DNA interactions within intact cells, advancing our understanding of cellular processes.

Red light, green light: flickering fluorophores reveal biochemistry in cells

Understanding protein interactions in live cells is revolutionizing our knowledge of cellular behavior.
The PAPA-fSMT method allows detailed study of protein complex dynamics during gene transcription.

'Phenomenal' tool sequences DNA and tracks proteins - without cracking cells open

The new microscopy technique enables imaging of proteins and DNA interactions within intact cells, advancing our understanding of cellular processes.
moreprotein-interactions
#gene-regulation

Mystery Droplets Inside Cells May Play Vital Roles in Life

Biomolecular condensates challenge traditional views of cell organelles, suggesting they play crucial roles in cell function and disease.

Two U.S. scientists win Nobel Prize in Physiology, Medicine

Victor Ambros and Gary Ruvkun won the 2024 Nobel Prize for their discovery of microRNA and its role in gene regulation.
Their work is fundamental for understanding cell development and potential future applications.

Author Correction: piRNA processing by a trimeric Schlafen-domain nuclease - Nature

Non-coding RNAs are essential for gene regulation and maintaining cellular functions.

Mystery Droplets Inside Cells May Play Vital Roles in Life

Biomolecular condensates challenge traditional views of cell organelles, suggesting they play crucial roles in cell function and disease.

Two U.S. scientists win Nobel Prize in Physiology, Medicine

Victor Ambros and Gary Ruvkun won the 2024 Nobel Prize for their discovery of microRNA and its role in gene regulation.
Their work is fundamental for understanding cell development and potential future applications.

Author Correction: piRNA processing by a trimeric Schlafen-domain nuclease - Nature

Non-coding RNAs are essential for gene regulation and maintaining cellular functions.
moregene-regulation

Author Correction: UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis - Nature

Collaborative research in cell biology can lead to significant advancements.
Integrating expertise from multiple institutions enhances scientific inquiry and innovation.

Your cells are dying. All the time.

Understanding the various modes of cell death can lead to improved treatments for diseases such as cancer and infections.

Cracking the tubulin code: enzyme structures offer clues to microtubule control

Microtubules' functionality is governed by a 'tubulin code' formed through specific modifications.

How Did the First Cells Arise? With a Little Rain, Study Finds.

Rain may have been crucial to the emergence of life, influencing the formation of protocells that led to early cellular evolution.

Leonard Hayflick, Who Discovered Why No One Lives Forever, Dies at 98

Leonard Hayflick discovered that human cells can only divide a limited number of times, setting a natural cap on human lifespan.

Bridging structural and cell biology with cryo-electron microscopy - Nature

Cryo-EM has revolutionized the study of large, functional complexes in structural biology.
The interplay between cryo-EM and cryo-electron tomography shows promise in visualizing macromolecules in their natural context.
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