Jacqueline Tabler developed a novel experiment involving grafting embryonic cells to explore the function of the enzyme PAR-1. After struggling to replicate previous findings, she had a dream that inspired her to transplant cells expressing PAR-1 onto embryos lacking it. This led to the discovery of PAR-1's role in controlling cell division orientation. Tabler emphasizes the importance of curiosity and creativity in science, noting that risk-taking enhances leadership and innovation in research.
"I had to learn that what set me apart - my curiosity and creativity - was positive," Tabler explains. In other words, it "was a feature, not a bug".
"It was a fantastical answer," she says. "I knew what I had to do was graft from one embryo to another embryo, follow the tissue, and then I would figure it out."
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