This article discusses the significance of plasma membrane integrity in cellular functions and introduces a novel 384-well cellular stretch system. This system screened over 10,000 siRNAs and revealed NINJ1 as a key protein that regulates the mechanical strain-induced rupture of the plasma membrane. Importantly, NINJ1 operates independently of traditional cell death pathways, indicating its essential role in maintaining membrane integrity when subjected to mechanical forces, providing insights into cellular responses to physical strain.
In our study, we investigated whether large molecules influence plasma membrane integrity under mechanical strain and identified NINJ1 as a key regulator of membrane rupture.
The findings reveal that NINJ1 functions independently of cell death programs, demonstrating its critical role in plasma membrane integrity under applied mechanical forces.
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