As for side effects, the companies reported that little had changed from previous analyses; adverse events were similar between the two groups. The top side effects linked to the vaccine were fatigue, injection site pain, and chills. The results "highlight the potential of a prolonged benefit" of the vaccine combined with Keytruda in patients with high-risk melanoma," Kyle Holen, a senior vice president at Moderna, said. They also "illustrate mRNA's potential in cancer care," he said, noting that the company has eight more Phase 2 and Phase 3 trials going for mRNA vaccines against a variety of other cancers, including lung, bladder, and kidney cancers.
The 70-year-old former software engineer has successfully restored most of his foreskin, a process he started in his 60s. In this edition of the Secret Lives of Men, he tells the story of why he returned his penis to its natural state and how he became a moderator of a foreskin-restoration subreddit, where he teaches others how to tug their missing foreskins back into existence.
AI plays an important role-but not by fixing fragmented data on its own. The work of organizing, connecting, and interpreting healthcare information still belongs to people and the systems they build. Where AI helps is after that foundation is in place: by bringing the right information forward at the right time, reducing the effort it takes to find what matters, and supporting better decisions in the moment of care.
There's a strange moment that happens the first time you watch botox kick in. One day you're squinting at your reflection and see the familiar lines crease across your forehead. A few days later, you raise your eyebrows andnothing. The skin stays put. It's subtle, even anticlimactic, but it's also the clearest proof that the world's most famous anti-wrinkle injection isn't magic or mystery.
A study led by Stanford Medicine researchers has found that an injection blocking a protein linked to aging can reverse the natural loss of knee cartilage in older mice. The same treatment also stopped arthritis from developing after knee injuries that resemble ACL tears, which are common among athletes and recreational exercisers. Researchers note that an oral version of the treatment is already being tested in clinical trials aimed at treating age-related muscle weakness.
All UK children could be offered screening for type 1 diabetes using a simple finger-prick blood test, say researchers who have been running a large study. Currently, many young people go undiagnosed and risk developing a life-threatening complication called diabetic ketoacidosis that needs urgent hospital treatment. Identifying diabetes earlier could help avoid this and mean treatments to control problematic blood sugar levels can be given sooner.
If we really invest in longevity science, we have a chance to build a better future. It's gonna be better in one very simple way. There's gonna be a lot less disease. At the moment, aging is the leading cause of death globally. Over a hundred thousand people die every single day of cancer, of Alzheimer's, of the increased risk of infectious disease that comes along with growing older.
Publisher Correction: Multiple oestradiol functions inhibit ferroptosis and acute kidney injury Publisher Correction Open access Published: 21 January 2026 Wulf Tonnus orcid.org/0000-0002-9728-14131 na1, Francesca Maremonti2 na1, Shubhangi Gavali orcid.org/0000-0003-2876-14532 na1, Marlena Nastassja Schlecht orcid.org/0000-0001-8893-53261, Florian Gembardt2, Alexia Belavgeni orcid.org/0000-0001-6311-58583, Nadja Leinung2, Karolin Flade orcid.org/0009-0009-5449-28251, Natalie Bethe1,
When Lola was eight years old, she went through a massive growth spurt and started developing acne. Her mother, Elise, thought Lola was just growing fast because of genes inherited from her father. But when she noticed that Lola had grown pubic hair too, she was floored. A visit to an endocrinologist in 2023 confirmed that Lola's brain was already producing hormones that had kick-started puberty.
A common diabetes medication does not help people with peripheral artery disease (PAD) and without diabetes walk farther, according to results from a major U.S. clinical trial published in JAMA. Peripheral artery disease (PAD) is a serious condition that affects blood flow to the legs, making walking painful and difficult. It impacts approximately 12 million adults in the U.S. and is linked to higher risks of heart attack and stroke.
"As we get older, the immune system is shifting away from good inflammation," which is the body's short-term, acute response to fend off injury or infection and promote healing, explains Dr. Thomas Marron, one of the researchers leading the new study. Marron directs early phase clinical trials at The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai.
An international trial is examining whether a finger-prick blood test could be used to help diagnose Alzheimer's disease. The study, involving 1,000 volunteers aged over 60 in the UK, US and Canada, will aim to detect biomarkers associated with the condition. Dr Michael Sandberg, a London GP, was encouraged to take part in the study after witnessing his mother's slow decline from Alzheimer's disease. He had a negative result from the tests and said it was "a huge relief".
Our brain interprets grief as stress. As a result, it activates our stress-response systems, especially the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system. These systems release stress hormones such as cortisol and adrenaline, which are meant to protect the body in short-term crises. In acute grief, these responses are adaptive. They help us cope with shock and disruption. If unresolved, however, the same systems can become dysregulated.
"I ain't gonna lie to you, I'm in the best shape of my life right now," Lewis said on "The Beast and the Cowboy" pocast. "Mentally, physically, everything's going great right now. The UFC provided me with some great peptides, and I've been taking it every day, and I've been feeling the difference."
The human brain, which is suspended in clear cerebrospinal fluid inside the skull, can also be impacted by the effects of microgravity - in a surprisingly tangible way. As detailed in a new study published by an international team of researchers in the journal PNAS, the brain "shifts upward and backward within the skull following spaceflight, with sensory and motor regions exhibiting the largest shifts."
EMPAVELI is the first and only approved treatment for C3G and IC-MPGN across pediatric patients 12+, adults, and post-transplant recurrence. That's roughly 5,000 patients in the U.S., with EMPAVELI holding exclusive approval for about two-thirds. Add the European CHMP positive opinion in December 2025, and you have a rare disease franchise with global expansion potential and pricing power that typically commands gross margins north of 90%.
A Colorado endocrinologist helped spark a quiet revolution in weight care by changing how primary care clinics talk about - and treat - obesity. Instead of vague advice to "eat less and exercise more," a new system called PATHWEIGH gave patients a clear, judgment-free path to real medical support for weight management.
For example, when it was asked what the normal range for liver blood tests was, the AI would give false numbers due to lack of information. Nationality, age, and sex are all factors that play a role in determining the correct results. Therefore, someone could believe they are healthy when they should have actually been seeking medical attention. "Google's AI Overviews can put inaccurate health information at the top of online searches, presenting a risk to people's health,"
Morry Kernerman, an accomplished violin prodigy, commits YouTube recordings of classical music to memory, hikes in a hilly ravine with his son and volunteers to teach music in South America. As he prepares to celebrate his 101st birthday next week, Kernerman is convinced that music has played an outsized role in contributing to his long and active life. The Toronto resident is what's known as a super-ager, someone 80 or up who retains the memory abilities of those in their 40s or 50s.
Eduardo Vilar-Sanchez has spent more than 10 years pursuing a goal that seemed very distant, but which he now sees as a little closer: to develop a preventive vaccine against cancer. The physician and researcher is leading a study that presented the first promising results of a colon cancer vaccine in a small group of patients suffering from a rare disease that makes them 17 times more likely to develop colon cancer than the general population.
Mucopolysaccharidosis type II (MPS II), or Hunter syndrome, is a rare genetic disorder primarily affecting boys, caused by a deficiency in the enzyme needed to break down sugar molecules. This harmful buildup in cells and tissues impacts multiple body systems, causing frequent infections, organ enlargement and developmental disabilities. Management involves supportive care and enzyme replacement therapy, as there is currently no cure,
The Food and Drug Administration commissioner's effort to drastically shorten the review of drugs favored by President Donald Trump's administration is causing alarm across the agency, stoking worries that the plan may run afoul of legal, ethical, and scientific standards long used to vet the safety and effectiveness of new medicines. Marty Makary's program is causing new anxiety and confusion among staff already rocked by layoffs, buyouts, and leadership upheavals, according to seven current or recently departed staffers.
Try hard enough, we are often told, and eventually you'll get what you want. But sometimes the hardest - and bravest - thing to do, is to stop trying. After years of hoping to start a family, including the painful rollercoaster of fertility treatment and a devastating miscarriage on Christmas day, Caroline Stafford, found the only way to find some kind of peace again was to accept it was not going to happen and to build a different future.
The company just raised its quarterly dividend to $0.63 in January 2026, a 6.8% increase from the prior $0.59 rate. That puts the annual payout at $2.52 per share with a yield around 1.9%. Not eye-popping, but the safety and growth profile more than compensate. Abbott generated $6.35 billion in free cash flow in 2024 against $3.84 billion in dividend payments.
After losing both of his parents to cancer, Tom set out to challenge a healthcare system that often waits for symptoms instead of identifying risk early. What began in Deerfield Beach, Florida, has grown into a multi-location preventative imaging company serving communities across the state. Life Imaging Fla focuses on preventative heart and full-body screenings. These services give people access to advanced imaging that is typically only approved once symptoms appear. The goal is straightforward: identify disease earlier, when people still have time, options, and control.
It's a watershed moment in aesthetic medicine, resonating across age groups. "Younger people are coming in with concerns about texture, tone, inflammation, early laxity, and how their skin behaves under stress," observes Dr. David Jack, an aesthetic doctor renowned for his light touch. "While more mature patients - many of whom have already had filler - are increasingly aware that volume alone does not age well if the architecture beneath it continues to degrade."