Medicine

Medicine

A whole slew of next-generation obesity drugs are on the horizon, some already advanced enough in clinical trials to be looking as good as-if not better than-those already on the market. The novel medications continue to push the upward limits of weight loss, now to almost 25 percent of body weight on average, but they also differ in their modes of action. They target different cells and different parts of cells in the brain and body.

Correction to: Nature https://doi.org/10.1038/nature19804 Published online 7 September 2016 In the version of the article initially published, in the Day 11 row of Extended Data Fig. 3c, the Chloroquine image was a duplicate of the BRD7929, 25 image from the same row. The correct Chloroquine image has now been added to Extended Data Fig. 3c, as seen in Fig. 1, below.

Caffeinated beverages cause an acceleration of heart rate, they cause acceleration of blood pressure. That's why if you're having your blood pressure checked, don't drink caffeinated beverages. As there is an association with heart rhythm disorders and caffeinated beverages.

In the early hours of 28 May 2005, Isabelle Dinoire woke up in a pool of blood. After fighting with her family the night before, she turned to alcohol and sleeping tablets to forget, she later said. Reaching for a cigarette out of habit, she realized she couldn't hold it between her lips. She understood something was wrong. Isabelle crawled to the bedroom mirror. In shock, she stared at her reflection:

Dr Ariel N. Rad is a leading Board certified plastic surgeon known for his precise, evidence-based approach to facelift and aesthetic medicine. He built his career on disciplined training, scientific rigor, and a belief that natural results come from deep understanding rather than trends. After completing his residency at Johns Hopkins, he co-founded SHERBER+RAD in Washington, D.C. with his wife, dermatologist Dr Noëlle Sherber. Together, they created one of the first fully integrated practices combining dermatology, facial aesthetic surgery, and curated skincare under one roof.

Researchers at Zhejiang University in Hangzhou, China, figured out how to precisely control a knot's geometry and friction so that they could 'program' it to open when tugged on with a given force. This allows a surgeon - or a robot - stitching up a wound to pull a suture closed with just the right amount of force, simply by tugging the free end of the knotted thread and stopping when the knot unfurls.

Essesi Design Studio designs Nimble, a concept have lost. It uses a modular 3D printed prosthetic fin that can help athletic amputees swim again. An attachable technology, the assistive object replaces the foot and lower leg that userscarbon fiber for the shell, and inside this main body sits a lattice structure made of rubber material. This part bends during movement, so in this case, when the swimmer kicks, the lattice structure flexes, creating thrust that moves them forward through water.

Person A said she was subjected to xenophobic behaviour from colleagues, including Miss Njoku, while working in a respiratory ward at St Mary's Hospital in Paddington in 2021. Person A said the senior nurse called her a Polish cow, Polish idiot, swine nose, stupid old cow and an old woman and complained to managers but no investigation took place. Person A said the encounter left them feeling very nervous whenever Miss Njoku was on duty

Researchers report that people who have more muscle and a lower visceral fat to muscle ratio tend to show signs of a younger biological brain age. This conclusion comes from a study that will be presented next week at the annual meeting of the Radiological Society of North America (RSNA). Visceral fat refers to the fat stored deep in the abdomen around key internal organs.

Sir Terence English had to fight for the right to carry out the surgery at Papworth Hospital in Cambridge in 1979, after resistance from the public and the government. The operation that paved the way to future transplants took place in August that year on 52-year-old Keith Castle, who lived for more than five years afterwards. Sir Terence's family said he died on Sunday at his home in Iffley in Oxford, six days after having a stroke.

The easiest way to describe fascia is to think about the structure of a tangerine, says Natasha Kilian, a specialist in musculoskeletal physiotherapy at Pure Sports Medicine. You've got the outer skin, and beneath that, the white pith that separates the segments and holds them together. Fascia works in a similar way: it's a continuous, all-encompassing network that wraps around and connects everything in the body, from muscles and nerves to blood vessels and organs.

However, the 2024 Cass review of NHS gender identity services for children and young people found there was insufficient/inconsistent evidence about the effects of puberty suppression on psychological or psychosocial wellbeing, cognitive development, cardio-metabolic risk or fertility. NHS England subsequently announced children with gender dysphoria would no longer receive puberty blockers as routine practice, with their use confined to research settings.

There's plenty of encouraging news for people taking GLP-1 drugs like Ozempic to lose weight and reduce the risk of diabetes: countless people who have lost weight while using it and seen other health benefits as a result. But along with the good news come some bleaker aspects, with some people taking these drugs and reporting feelings of nausea as a result.

In fact, as nations around the world decriminalize and legalize cannabis, doctors are also discovering (and rediscovering) many potential uses and health benefits. Many people use cannabis for sleep management, pain management, to reduce inflammation, and as a muscle relaxant. In addition, clinical studies have shown that cannabis often serves as an effective treatment for chronic pain in adults, chemotherapy-induced nausea and vomiting, and multiple sclerosis-related spasticity.

Every weekday afternoon, Harvard neurologist Jasmeer Chhatwal gets up from his desk, heads out of the office, and walks about three-quarters of a mile to get a cup of coffee from a neighborhood cafe. There's a perfectly good coffee maker in the office, but the afternoon ritual isn't (just) about caffeine. The 20-minute stroll is helping to stave off symptoms of brain aging like memory loss, according to Chhatwal's research.

"There are signals that GLP-1s could be the first true longevity drug," Alex Zhavoronkov, the founder and CEO of Insilico Medicine, said Monday at the Fortune Innovation Forum in Kuala Lumpur, Malaysia.

Miliary tuberculosis (MTB) is a severe form of tuberculosis in which the instigating bacteria- Mycobacterium tuberculosis or potentially a relative that infects cows and deer, Mycobacterium bovis -spread widely through the body and create small lesions. The name "military" dates back to 1700, when a physician noted that the specks resembled millet seeds. While Mycobacterium can spread through the air and are often found in the lungs, the bacteria can strike anywhere in the body.

So if you may remember, years ago now, I started talking about building my own not-for-profit healthcare service for trans adults and trans youth,

Researchers have developed a skin-permeable polymer that can deliver insulin into the body, which they say could one day offer an alternative to injections for diabetes management. The skin's structure presents a formidable barrier to the delivery of large drugs but in this work a team show that their polymer can penetrate though the different layers without causing damage. Insulin attached to this polymer was able to reduce blood glucose levels in animal models for diabetes at a comparable speed to injected insulin.

Therapeutic genome-editing efforts, including more than 70 clinical trials so far, have predominantly used programmable nucleases, base editors or prime editors to disrupt or correct disease-associated genes in an allele-specific manner. These approaches have proven to be effective in patients or in animal models for the treatment of disorders such as sickle-cell disease6,7, T cell leukaemia8, hypercholesterolaemia9,10, alpha-1-antitrypsin deficiency10, chronic granulomatous disease11, progeria12, spinal muscular atrophy13, prion disease14, alternating hemiplaegia of childhood15 and many other genetic diseases. Although allele-specific therapeutic genome-editing strategies offer treatments for many serious diseases with few treatment options, the breadth of the global genetic disease crisis,

termination of federal grant funding was rare prior to 2025.

The findings supplement previous results from the PARTNER 3 trial, which found that patients who underwent a transcatheter aortic valve replacement, or TAVR - a minimally invasive procedure in which the narrowed aortic valve is replaced via percutaneous access with wires and catheters through the femoral artery - demonstrated similar five-year survival rates to patients who underwent traditional aortic-valve replacement surgery.

In the US alone, 12% of the population have reported using injectable weight loss drugs, such as Wegovy/Ozempic, Zepbound and Saxenda, over the past year. That's more than double the number recorded in early 2024. In European countries, demand is also on the rise: In the UK, for example, a survey found that 21% of the public had accessed an online or in-person pharmacy in the past year to obtain weight loss medication.

Picture a plastic surgeon's office. You might imagine a sleek Los Angeles practice, with discreet entrances meant to conceal celebrities from the paparazzi. Maybe a Dallas high-rise, where monied housewives spend on postpartum mommy makeovers. Or a Miami location, where influencers and OnlyFans stars film TikToks of their BBLs. One city you might not think of is Washington DC. But its buttoned-up reputation belies a newly buzzing industry.