Chronic inflammation is a central driver of pathological fibrosis after ischaemic or haemodynamic stress, but strategies that locally rebalance injurious and reparative immune responses without systemic immunosuppression are lacking.
The human maternal-fetal interface (MFI) is a transient hemi-allogeneic amalgam in which maternal decidual stromal cells (DSCs) support placental attachment, recruit immune cells and create a tolerogenic milieu for patterning fetal cytotrophoblast invasion.
Out of suffering have emerged the strongest souls; the most massive characters are seared with scars. I was born with spina bifida and faced multiple surgeries, leading to uncertainty about my ability to walk again. Despite the fear and pain, I refused to accept paralysis as my fate.
"People tend to immediately think of neurons when they think about how the brain works. But we're finding that astrocytes, what we used to think of as just secondary support cells, are also participating in how our brains regulate how much we eat."
The HIV ward, the scene of graphically ill patients when I was training, is long closed because it's no longer needed in most rich countries. When my young neighbour had a stroke, doctors cleverly retrieved the clot suffocating his artery, not just saving his life but also returning it to its full potential.
"For the ones who are confined in certain spaces or cannot do it independently, this is a great opportunity to transport them to a different reality from the ones that they are currently living in while keeping them active," Munoz told CBC Hamilton from his lab on Laurier's Brantford campus.
Michael Jackson, during his visit to my clinic, took away between 20 and 30 high-value products, each costing up to €500. It was quite a sight.
The probability that frozen tissue will benefit the person who froze it is remote. The chance of developing acute lymphoblastic leukemia, the most common childhood cancer, currently stands at one in 20,000.
On that sunny March morning, in a small health center in Lobamba, a rural area of Eswatini, this 32-year-old sex worker has just become one of the first people in the world to receive lenacapavir, a drug that, administered twice a year, offers nearly 100% protection against HIV.
"This argues for the need to sustain such policies and shows that it is possible to right the wrongs retroactively, which is a powerful idea," said Kenneth Michelson, MD, MPH, associate professor of Pediatrics in the Division of Emergency Medicine and a co-author of the study.
Small organic molecules underpin modern life, from medicines and flavours to advanced materials. Much of this functional diversity comes from shape: modest changes in a molecule's 3D structure can completely change its properties.
When Lorraine Kelly Donnelly felt a cramp in her left hand at the start of 2025, she didn't think anything of it. But when a week later the pain was still there, she made an appointment to see her GP.
The Stanley Family Foundation announced another $280 million for the Stanley Center for Psychiatric Research at Broad Institute earlier this month, bringing its total contributions to the Massachusetts-based nonprofit over $1 billion.
