#gene-editing

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#crispr

No CRISPR: oddball 'jumping gene' enzyme edits genomes without breaking DNA

A molecular oddity in bacteria could lead to precise genome redesign through jumping genes, surpassing CRISPR limitations.

Jennifer Doudna on the Brave New World Being Ushered In by Gene Editing

CRISPR technology offers transformative potential for medicine and agriculture but raises significant ethical and societal concerns.

Why Jennifer Doudna is one of Fast Company's 10 most innovative people of the last 10 years

CRISPR technology has revolutionized gene editing in medicine, impacting various diseases and treatment methodologies.

New technique opens the door to large-scale DNA editing to cure diseases

Gene editing corrects diseases like sickle cell anemia by replacing a defective gene with a working one using CRISPR technology.
New genetic editing mechanism uses jumping genes to introduce long DNA sequences with potential for higher precision in editing and genome alteration.

From cloning to CRISPR: The center that created Dolly designs epidemic-resistant animals

Roslin Institute has shifted focus from cloning to CRISPR gene editing to enhance animal disease resistance and improve livestock health.

DNA-based bacterial parasite uses completely new DNA-editing method

Having a variety of gene-editing technologies, including CRISPR variants, presents the opportunity to balance factors like convenience, precision, and error rates for improved genome editing.

No CRISPR: oddball 'jumping gene' enzyme edits genomes without breaking DNA

A molecular oddity in bacteria could lead to precise genome redesign through jumping genes, surpassing CRISPR limitations.

Jennifer Doudna on the Brave New World Being Ushered In by Gene Editing

CRISPR technology offers transformative potential for medicine and agriculture but raises significant ethical and societal concerns.

Why Jennifer Doudna is one of Fast Company's 10 most innovative people of the last 10 years

CRISPR technology has revolutionized gene editing in medicine, impacting various diseases and treatment methodologies.

New technique opens the door to large-scale DNA editing to cure diseases

Gene editing corrects diseases like sickle cell anemia by replacing a defective gene with a working one using CRISPR technology.
New genetic editing mechanism uses jumping genes to introduce long DNA sequences with potential for higher precision in editing and genome alteration.

From cloning to CRISPR: The center that created Dolly designs epidemic-resistant animals

Roslin Institute has shifted focus from cloning to CRISPR gene editing to enhance animal disease resistance and improve livestock health.

DNA-based bacterial parasite uses completely new DNA-editing method

Having a variety of gene-editing technologies, including CRISPR variants, presents the opportunity to balance factors like convenience, precision, and error rates for improved genome editing.
morecrispr

CRISPR builds a big tomato that's actually sweet

Editing two genes in tomatoes can significantly boost their sweetness and flavor.
#agriculture

Scientists dismayed as UK ministers clear way for gene editing of crops - but not animals

The UK government will allow gene-edited crops but not animals, disappointing some scientists concerned about livestock health and productivity.

RealAg Radio: Gene-editing, seed regulatory modernization, and GREET model implications on canola, May 8, 2024

The episode covers topics on gene editing, seed regulatory modernization, canola industry impact, and water rationing in Southern Alberta.

Scientists dismayed as UK ministers clear way for gene editing of crops - but not animals

The UK government will allow gene-edited crops but not animals, disappointing some scientists concerned about livestock health and productivity.

RealAg Radio: Gene-editing, seed regulatory modernization, and GREET model implications on canola, May 8, 2024

The episode covers topics on gene editing, seed regulatory modernization, canola industry impact, and water rationing in Southern Alberta.
moreagriculture
#neuroscience

A Novel Discovery Hints At Why We Stop Producing New Brain Cells - And What We Can Do About It

Neural stem cells' decline with age can be linked to glucose levels, highlighting a potential pathway for combating cognitive decline.

CRISPR helps brain stem cells regain youth in mice

Disabling a specific metabolism-related gene can rejuvenate neural stem cells, enhancing their ability to produce new neurons as organisms age.

Daily briefing: How to win a Nobel prize: what past winners can tell you about your chances

New Îł-ray radiation linked to thunderstorms may explain lightning initiation.
Gene editing rejuvenates brain stem cells in ageing mice, hinting at potential therapies.
White noise boosts growth in fungal microbes, altering their genetic expression.

A Novel Discovery Hints At Why We Stop Producing New Brain Cells - And What We Can Do About It

Neural stem cells' decline with age can be linked to glucose levels, highlighting a potential pathway for combating cognitive decline.

CRISPR helps brain stem cells regain youth in mice

Disabling a specific metabolism-related gene can rejuvenate neural stem cells, enhancing their ability to produce new neurons as organisms age.

Daily briefing: How to win a Nobel prize: what past winners can tell you about your chances

New Îł-ray radiation linked to thunderstorms may explain lightning initiation.
Gene editing rejuvenates brain stem cells in ageing mice, hinting at potential therapies.
White noise boosts growth in fungal microbes, altering their genetic expression.
moreneuroscience

2 Biotech Bets to Buy in September

Biotech investing offers both high rewards and significant risks, necessitating resilience and a long-term commitment from investors.

Daily briefing: How long can we hold off more controversial 'CRISPR babies'?

Gene editing of babies is being considered by some scientists despite ongoing controversies.
Research indicates that environmental factors significantly impact brain ageing, particularly in socio-economically disadvantaged regions.
The Oropouche virus is expanding its range, raising public health concerns due to recent fatalities.

Designer Babies Are Here - So Why Aren't We Talking About It?

Scientists often overlook the societal implications of their research due to a lack of training and incentives.
#progeria

A disease that makes children age rapidly gets closer to a cure

Gene editing may offer hope for treating ultrarare conditions like progeria, potentially paving the way for treatments for other genetic diseases.

A Disease That Makes Children Age Rapidly Gets Closer to a Cure

A cure for progeria through gene editing may be imminent.

A disease that makes children age rapidly gets closer to a cure

Gene editing may offer hope for treating ultrarare conditions like progeria, potentially paving the way for treatments for other genetic diseases.

A Disease That Makes Children Age Rapidly Gets Closer to a Cure

A cure for progeria through gene editing may be imminent.
moreprogeria
#medical-research

These gene-edited pigs that provide organs for humans listen to Tom Petty and enjoy luxury accommodations

Pioneering gene-edited pig organ transplants show future promise in organ transplantation.

Woman Back on Dialysis After Doctors Remove Failing Pig Kidney

Xenotransplantation, using gene-edited pig kidneys, faced challenges in managing blood flow and immune response, leading to early organ removal.

These gene-edited pigs that provide organs for humans listen to Tom Petty and enjoy luxury accommodations

Pioneering gene-edited pig organ transplants show future promise in organ transplantation.

Woman Back on Dialysis After Doctors Remove Failing Pig Kidney

Xenotransplantation, using gene-edited pig kidneys, faced challenges in managing blood flow and immune response, leading to early organ removal.
moremedical-research

RealAg Radio: Conservation easements, spring rainfall, and switching corn hybrids, May 13, 2024

Discussion on moisture levels, corn hybrids, gene-editing, and conservation easements in agriculture.

CRISPR gene editing trial treats inherited blindness DW 05/06/2024

CRISPR-Cas9 gene editing restored vision in people with rare inherited blindness, improving sight without serious side effects.

Health Canada issues final decision, clearing regulatory pathway for gene-edited crops

Gene-edited crops in Canada now considered non-novel, treated like traditional breeds.

AI & robotics briefing: What running robots tell us about gaits

AI is used to design new gene-editing tools like CRISPR proteins, expanding capabilities beyond natural systems.
Researchers have adapted deep learning transformers for quantum computers, showing potential accuracy benefits over classical models.

Nobel laureates call on EU to relax rules on genetic modification

34 Nobel prize winners are urging the EU to relax rules on genetic modification before a key vote on gene editing.
They argue that gene editing techniques could make crops more resistant to disease and extreme weather events caused by climate change.

A Gene-Edited Pig Liver Was Attached to a Person-and Worked for 3 Days

Scientists used gene editing to make 69 genetic edits to a pig, including knocking out three pig genes and inserting seven human genes.
Previous attempts with unmodified pig livers failed within hours, but the pig livers with genetic edits in the Penn study showed stable blood flow and no signs of inflammation.

FDA Approves World's First Crispr Gene-Editing Drug for Sickle-Cell Disease

The US has approved the world's first medicine using Crispr technology.
Crispr technology has the potential to treat genetic conditions that are difficult to treat.

FDA approves first gene-editing treatments for human illness

The FDA has approved the first gene-editing treatments for sickle cell disease, marking a milestone in the field of gene-editing.
The treatments have the potential to provide more targeted and effective treatments for rare diseases with limited current options.

F.D.A. Approves Sickle Cell Treatments, Including One That Uses CRISPR

The Food and Drug Administration has approved the first gene editing therapy and conventional gene therapy for sickle cell disease.
Obstacles to treatment include limited access to authorized medical centers, individualized procedures, and high costs.

The CRISPR Era Is Here

Gene-editing technology CRISPR has successfully treated a patient with sickle-cell disease, providing hope for future treatments.
The treatment resulted in the patient living virtually symptom-free, with 29 out of 30 eligible patients experiencing zero pain crises after treatment.
#gene editing

New Gene Editing Treatment Cuts Dangerous Cholesterol in Small Study

Gene editing treatment shows promise in lowering cholesterol levels in patients with severe heart disease
Treatment has the potential to transform preventive cardiology

Crispr gene editing shown to permanently lower high cholesterol

Researchers have shown that a single infusion of a novel gene-editing treatment can reduce cholesterol in a small test on people.
The gene-editing treatment aims to permanently lower cholesterol by using Crispr to edit a gene in the liver.
Preliminary results of the experiment were presented at the American Heart Association's annual meeting.

A Single Infusion of a Gene-Editing Treatment Lowered High Cholesterol

Researchers have shown that a single infusion of a gene-editing treatment can reduce cholesterol levels in people.
The treatment aims to permanently lower cholesterol by using Crispr to edit a gene in the liver, and initial results show significant reductions in LDL cholesterol.
Gene editing could provide a lasting option for treating hereditary high cholesterol, replacing the need for long-term medication.

Goodbye Statins? New Gene Editing Therapy Slashes High Cholesterol

A novel gene editing therapy using base editing lowered "bad" cholesterol levels in individuals with FH by as much as 55 percent.
The therapy could potentially provide a single-course treatment option for deep LDL lowering for decades without the need for daily pills or intermittent injections.

The U.K. approved its first CRISPR gene-editing drugand the U.S. is expected to follow

U.K. regulators have approved the first-ever CRISPR gene-editing drug for the treatment of sickle cell disease and beta thalassemia.
The therapy has shown success in clinical trials and is expected to reach the U.S. by the end of the year.
The gene editing treatment modifies stem cells to boost the production of functional hemoglobin, providing a fix at the DNA level.

UK authorizes first gene therapy for treating sickle cell disease

The UK's MHRA has approved the use of a gene-editing therapy for patients with sickle cell disease and beta thalassemia.
The therapy, called Casgevy, is the first-ever approved therapy that uses CRISPR-based gene editing technology.
The therapy has shown high efficacy in relieving severe pain associated with these blood disorders and could potentially replace the current standard of care.

New Gene Editing Treatment Cuts Dangerous Cholesterol in Small Study

Gene editing treatment shows promise in lowering cholesterol levels in patients with severe heart disease
Treatment has the potential to transform preventive cardiology

Crispr gene editing shown to permanently lower high cholesterol

Researchers have shown that a single infusion of a novel gene-editing treatment can reduce cholesterol in a small test on people.
The gene-editing treatment aims to permanently lower cholesterol by using Crispr to edit a gene in the liver.
Preliminary results of the experiment were presented at the American Heart Association's annual meeting.

A Single Infusion of a Gene-Editing Treatment Lowered High Cholesterol

Researchers have shown that a single infusion of a gene-editing treatment can reduce cholesterol levels in people.
The treatment aims to permanently lower cholesterol by using Crispr to edit a gene in the liver, and initial results show significant reductions in LDL cholesterol.
Gene editing could provide a lasting option for treating hereditary high cholesterol, replacing the need for long-term medication.

Goodbye Statins? New Gene Editing Therapy Slashes High Cholesterol

A novel gene editing therapy using base editing lowered "bad" cholesterol levels in individuals with FH by as much as 55 percent.
The therapy could potentially provide a single-course treatment option for deep LDL lowering for decades without the need for daily pills or intermittent injections.

The U.K. approved its first CRISPR gene-editing drugand the U.S. is expected to follow

U.K. regulators have approved the first-ever CRISPR gene-editing drug for the treatment of sickle cell disease and beta thalassemia.
The therapy has shown success in clinical trials and is expected to reach the U.S. by the end of the year.
The gene editing treatment modifies stem cells to boost the production of functional hemoglobin, providing a fix at the DNA level.

UK authorizes first gene therapy for treating sickle cell disease

The UK's MHRA has approved the use of a gene-editing therapy for patients with sickle cell disease and beta thalassemia.
The therapy, called Casgevy, is the first-ever approved therapy that uses CRISPR-based gene editing technology.
The therapy has shown high efficacy in relieving severe pain associated with these blood disorders and could potentially replace the current standard of care.
moregene editing

U.K. Is First to Approve a CRISPR-Based Therapy, Covering Two Blood Disorders

The UK has authorized a gene-editing medicine for treating sickle cell disease and beta thalassemia, marking the first approval worldwide for a therapy based on CRISPR technology.
The therapy, known as Casgevy, involves editing a gene in a patient's stem cells to produce high levels of fetal hemoglobin.
Casgevy offers a potentially curative treatment option for these inherited blood disorders, reducing the need for chronic therapies and blood transfusions.

Sickle-Cell Treatment Created With Gene Editing Wins U.K. Approval

Regulators in Britain have approved the first treatment derived from CRISPR, called Casgevy, for sickle-cell disease and beta thalassemia.
About 2,000 patients in Britain are expected to be eligible for Casgevy treatment.
The FDA is expected to approve Casgevy for sickle-cell patients in the US in early December.

Researchers developed a gene-editing technology that reduces 'bad' cholesterol

A gene-editing treatment called VERVE-101 showed promising results in reducing cholesterol levels in patients with hereditary conditions.
The treatment used CRISPR editing techniques to turn off a cholesterol-raising gene in the liver, resulting in lower levels of LDL-C.
While the therapy has the potential to disrupt current high cholesterol treatments, further studies and FDA approval are needed before it can be widely available.

For the first time, gene-editing provides hints for lowering cholesterol

Preliminary results show that gene-editing can reduce high cholesterol levels in patients with a genetic condition.
More research is needed to confirm the safety and effectiveness of the treatment.
This could potentially provide a new way to prevent heart attacks and strokes.
#biotechnology

Gene editing's next big targets

Gene editing advances focus on fighting cancers and common diseases, exploring aging, editing RNA.

Can GMO crops promise food security? DW 06/19/2024

Gene editing technology is revolutionizing the biotech crop industry to ensure food security for a growing global population.

Scientists edit the genes of gut bacteria in living mice

Base editor modified gene in over 90% of E. coli in mice's gut microbiome without adverse effects.

Gene editing's next big targets

Gene editing advances focus on fighting cancers and common diseases, exploring aging, editing RNA.

Can GMO crops promise food security? DW 06/19/2024

Gene editing technology is revolutionizing the biotech crop industry to ensure food security for a growing global population.

Scientists edit the genes of gut bacteria in living mice

Base editor modified gene in over 90% of E. coli in mice's gut microbiome without adverse effects.
morebiotechnology

IV infusion enables editing of the cystic fibrosis gene in lung stem cells

The development of gene editing techniques faces challenges in targeting specific cells and tissues affected by genetic diseases, requiring innovative approaches for effective treatment.
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