Our research has revealed an important link between the gut microbiota and how the brain responds to stress in a time-specific way. The gut microbiome doesn't just regulate digestion and metabolism; it plays a critical role in how we react to stress, and this regulation follows a precise circadian rhythm.
The team identified specific gut bacteria that seems to be connection to both the body's circadian rhythm as well as the release of a particular stress hormone.
Using mice, the team examined how an altered gut microbiome interferes with the animals' internal clocks and stress hormones during a day's time. They found that depletion of gut microbiota led to hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis.
Limosilactobacillus reuteri displayed significant variation throughout the day, suggesting its role in the gut-brain connection and stress response.
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