Cancer
Cancer

NCI's CPTAC releases new proteogenomic dataset

Takeaway 1: The National Institutes of Health is releasing a comprehensive dataset that standardizes genomic, proteomic, imaging, and clinical data from individual studies of over 1,000 tumors across 10 cancer types. This dataset will provide researchers from around the world with a publicly available resource to uncover new molecular insights into how cancers develop and progress.

Takeaway 2: The pan-cancer proteogenomic dataset, which is described in a paper published in Cancer Cell, builds on decades of technological advances in proteomic science. It supports the Biden-Harris Administration's Cancer Moonshotâ goal of accelerating cancer research through improved sharing of data.

Takeaway 3: The dataset's potential as a valuable resource for scientific discovery is demonstrated through two additional research papers published in Cell by CPTAC investigators. These papers explore the links between cancer driver mutations and protein patterns, as well as the associations between protein modifications and DNA repair, metabolism, and immunity across different tumor types. [ more ]

National Cancer Institute

NCI study challenges long-held beliefs about cell division

What
A new study suggests that cells preparing to divide can reverse this process and return to a resting state, challenging long-heldbeliefs about cell division. If interrupted early in their preparation to divide, cells were able to halt the division process, known as mitosis. The finding, led by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, and reported July 5, 2023, in Nature, could point toward more effective treatments to interrupt the process by which cancer cells divide quickly and spread.

National Cancer Institute

NCI awards $50 million for new Persistent Poverty Initiative

Today, the Biden-Harris Administration awarded $50 million to launch the Persistent Poverty Initiative, an initiative to alleviate the cumulative effects of persistent poverty on cancer outcomes by building research capacity, fostering cancer prevention research, and promoting the implementation of community-based programs.

MD Anderson Cancer Center

Clinical trial of new AhR inhibitor shows cancer might be even more wily than we thought

Researchers at MD Anderson - along with collaborators around the world - have been conducting a Phase I clinical trial of a drug called BAY 2416964 that can block AhR.Although the findings were disappointing, the drug may still play a valuable role in treating cancer when combined with other drugs, especially PD-1 checkpoint inhibitors.

MD Anderson Cancer Center

The next generation of CDK inhibitors is coming

Recent developments in CDK inhibitor research are yielding a new generation of more selective and potent CDK4 and CDK2 inhibitors.

MD Anderson Cancer Center

Stage IV colon cancer survivor grateful for MD Anderson

Before coming to MD Anderson, Bart Wilson was told there was no cure for stage IV colon cancer.The personalized care and treatment Bart received at MD Anderson helped him get back to living his life.

MD Anderson Cancer Center

Breast cancer survivor: Preventive surgery at MD Anderson caught my early-stage ovarian cancer

Carol Arnhart came to MD Anderson initially for triple-negative breast cancer treatment.But a risk-reduction surgery revealed she also had stage I ovarian cancer.

MD Anderson Cancer Center

Colorectal cancer screening: At what age should I get a colonoscopy?

What is the recommended age for a colonoscopy?When is it no longer recommended?We spoke with gastroenterologist Mazen Alasadi, M.D., to find out.

MD Anderson Cancer Center

Your questions about BCMA and multiple myeloma, answered

BCMA stands for B cell maturation antigen, and it's emerged as an important target in multiple myeloma.

MD Anderson Cancer Center

Leukemia specialist, amateur painter finds meaningful connection between art and medicine

Is there a common thread between art and medicine?Leukemia specialist and chair Hagop Kantarjian, M.D., thinks so.Find out what he believes that element is, and why he's completed more than 500 paintings since 1992.

MD Anderson Cancer Center

What is nose cancer?

Nose and sinus cancers occur when cancerous cells form in the nasal cavity or paranasal sinuses.To learn more about these rare types of cancer, we spoke with head and neck surgeon Ehab Hanna, M.D.

MD Anderson Cancer Center

Is a clinical trial right for me?

Wondering if a clinical trial is right for you?Use these answers to common clinical trial questions from Funda Meric-Bernstam, M.D., to help you have a more informed conversation with your care team.

MD Anderson Cancer Center

Updates in soft tissue sarcoma

What's new in treating sarcoma?Learn about findings from new research that MD Anderson experts are sharing at the 2023 ASCO Annual Meeting.

National Cancer Institute

11 months ago

ComboMATCH will test new combinations of cancer drugs

The National Cancer Institute (NCI) has launched a large precision medicine cancer initiative to test the effectiveness of treating adults and children with new drug combinations that target specific tumor alterations.Known as the Combination Therapy Platform Trial with Molecular Analysis for Therapy Choice (ComboMATCH), the initiative is the largest of its kind to test combinations of cancer drugs guided by tumor biology.

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National Cancer Institute

How to reduce the cancer death rate by at least 50% over the next 25 years

Researchers from the National Institutes of Health (NIH) have outlined opportunities for achieving President Biden and First Lady Biden's Cancer Moonshot℠ national goal of reducing the cancer death rate by at least 50% over the next 25 years.A study published April 17 in Cancer Discovery, led by researchers at the National Cancer Institute (NCI), part of NIH, has concluded that achieving this goal will require increased access to and use of interventions known to prevent common causes of cancer death.

National Cancer Institute

Pragmatica-Lung Study opens for patient enrollment

The National Cancer Institute, part of the National Institutes of Health (NIH), has helped launch a phase 3 randomized clinical trial ( NCT05633602) of a two-drug combination to treat patients with advanced non-small cell lung cancer (NSCLC).Called the Pragmatica-Lung Study (or S2302), this is one of the first NCI-supported clinical trials to use a trial design that removes many of the barriers that prevent people from joining clinical trials.

National Cancer Institute

Immunotherapy effective for lymphomatoid granulomatosis

Results from a clinical trial conducted by researchers at the National Institutes of Health (NIH) show that people with low-grade lymphomatoid granulomatosis who are treated with interferon alfa-2b, a type of immunotherapy, can live for decades after diagnosis.Lymphomatoid granulomatosis is a rare precancerous condition triggered by Epstein-Barr virus infection.

National Cancer Institute

Cancer Grand Challenges announces new funding opportunity

The National Cancer Institute (NCI), part of the National Institutes of Health, and Cancer Research UK have announced nine new research challenges aimed at tackling some of the most profound problems in cancer research.The global funding opportunity is part of the Cancer Grand Challenges program, an initiative launched by NCI and Cancer Research UK in 2020.

National Cancer Institute

NCI Director Monica Bertagnolli Breast Cancer Diagnosis

I was very recently diagnosed with early breast cancer.The prognosis is very favorable.The cancer is hormone receptorpositive, HER2-negative breast cancer and appears to be confined to the breast.I will need surgery and possibly additional treatment.As is the case for many people after a cancer diagnosis, I'm in a waiting period right now and there are things we don't know.

National Cancer Institute

Annual Report to the Nation shows progress against cancer

Overall cancer death rates continued to decline among men, women, children, and adolescents and young adults in every major racial and ethnic group in the United States from 2015 to 2019, according to the latest Annual Report to the Nation on the Status of Cancer.From 2014 to 2018, overall cancer incidence, or new cases of cancer, remained stable for men and children but increased for women and adolescents and young adults.

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National Cancer Institute

Atezolizumab approved for advanced alveolar soft part sarcoma

A clinical trial led by the National Cancer Institute (NCI), part of the National Institutes of Health, has resulted in the first approval of a treatment for advanced alveolar soft part sarcoma (ASPS).The immunotherapy drug atezolizumab (Tecentriq) was recently approved by the U.S. Food and Drug Administration (FDA) for the treatment of adults and children 2 years and older with ASPS that has spread to other parts of the body or cannot be removed by surgery.

MD Anderson Cancer Center

What is neoadjuvant immunotherapy for skin cancer?

Neoadjuvant immunotherapy is immunotherapy that's started before surgery.MD Anderson experts explain how, when and why it is used.

MD Anderson Cancer Center

What causes cervical cancer? 6 questions, answered

What causes cervical cancer?Can it be prevented?Gynecologic cancer surgeon Jolyn Sharpe Taylor, M.D., answers these questions and more.

MD Anderson Cancer Center

7 questions about chemo ports, answered

Cancer patients who undergo chemotherapy may receive a port as part of their treatment.Ervin Brown, M.D., explains how ports work and what to expect if you have one installed.

MD Anderson Cancer Center

'My first symptoms of ovarian cancer': Signs to look for and when to see a doctor

What are the symptoms of ovarian cancer?Three survivors share what they experienced, and gynecologic surgeon Jolyn Sharpe Taylor, M.D., weighs in on when to see a doctor.

MD Anderson Cancer Center

MD Anderson offers hope to patient with stage IV triple-negative breast cancer

If you are ready to make an appointment, select a button on the right.If you have questions about MD Anderson's appointment process, our information page may be the best place to start.

MD Anderson Cancer Center

RET inhibitors: A treatment for any RET-altered cancer

Some cancers are driven by a mutation in the RET gene or a rearrangement in gene's DNA.RET inhibitors target these genetic abnormalities to treat cancer.Vivek Subbiah, M.D., explains what patients should know.

MD Anderson Cancer Center

6 things we've learned about CAR T cell therapy

Since MD Anderson's first CAR T cell therapy clinical trial launched in 2015, we've cared for hundreds of patients undergoing CAR T cell therapy.Over the years, we've gained valuable insight into this game-changing treatment that trains a patient's immune system to find and kill cancer cells.With CAR T cell therapy, T cells that defend the body against disease are extracted from a cancer patient's blood.

MD Anderson Cancer Center

7 tips for reducing household toxins

It can be hard to know where to start when it comes to avoiding toxins that might increase your risk for cancer.Follow these tips from cancer researcher Melinda Yates, Ph.D.

MD Anderson Cancer Center

Germinoma caregiver: Why I wrote an open thank you note to MD Anderson

Retired nurse Paulette Roberson was so impressed by the care her son, Eric, received at MD Anderson for a pineal germinoma, that she is writing thank-you notes to every employee she and her family encountered during his appointments and hospitalizations.

MD Anderson Cancer Center

'How I knew I had lung cancer': Three survivors share their symptoms

What are the symptoms of lung cancer, and when do they warrant medical attention?Here, thoracic and cardiovascular surgeon Ara Vaporciyan, M.D., weighs in on when to see a doctor, and three survivors share how they discovered they had lung cancer.

MD Anderson Cancer Center

CAR T cell therapy puts smoldering and multiple myeloma survivor in remission

Myrna Youmans didn't know she had smoldering myeloma until she came to MD Anderson.Here, the 82-year-old found the expertise and treatments she needed to achieve remission.

MD Anderson Cancer Center

Ovarian cancer stages: How they are determined

When you receive an ovarian cancer diagnosis, your doctor will determine its stage to help determine the best treatment for you.Gynecologic oncologist Lauren Cobb, M.D., explains how ovarian cancer staging works - and how it's different from staging for other cancer types.

MD Anderson Cancer Center

6 fitness questions, answered

Getting enough exercise can be a big puzzle: When should you do it, how much and what type of exercise?Here are the answers to some of the most common exercise questions.

MD Anderson Cancer Center

Immunotherapy combination enables melanoma survivor to sail through retirement

After Paul McKinney was diagnosed with stage III melanoma, he enrolled in a clinical trial, where he received a new immunotherapy combination testing an LAG-3 antibody.

MD Anderson Cancer Center

Heart cancer: Insights on diagnosis, treatment and research

Cardiac angiosarcoma is the most common subtype of cardiac sarcoma, but they're still extremely rare.Vinod Ravi, M.D., shares diagnosis, symptoms and treatment for heart tumors.

MD Anderson Cancer Center

Retired oncologist: Four things I've learned as a six-time cancer survivor

After receiving six different cancer diagnoses of his own, Arthur Hamberger, M.D., has learned a few things over the years.

Here's his advice for other cancer patients.

MD Anderson Cancer Center

Hodgkin lymphoma, leukemia survivor: Targeted therapy clinical trial put me in remission

Algimante Daugelaite came to MD Anderson after exhausting her treatment options for Hodgkin lymphoma and leukemia in Lithuania.

MD Anderson Cancer Center

3 facts about Pancoast tumors

Pancoast tumors are a rare form of lung cancer that develop in the upper portion of the lungs.

MD Anderson Cancer Center

Prostate cancer survivor: I'm grateful for treatment at MD Anderson

When Ford Swift was diagnosed with prostate cancer, he came to MD Anderson for prostate brachytherapy using the MRI-assisted radiosurgery (MARS) technique.

MD Anderson Cancer Center

How to support cancer patients during mental health struggles

Feelings of anxiety, depression and grief can affect the mental health of cancer patients.

MD Anderson Cancer Center

Nodular melanoma: 5 questions, answered

Nodular melanoma is a type of skin cancer that can mimic benign conditions, including blood blisters and acne.

So, how do you know when to see a doctor?

We asked dermatologist Kelly Nelson, M.D.

MD Anderson Cancer Center