#peripheral-immune-tolerance

#peripheral-immune-tolerance

In 2001, Ramsdell and Brunkow made a key discovery while studying a mouse strain prone to autoimmune disease. Together, the researchers found that mice possessed a mutation of a gene they named "Foxp3," which they compared to the mutations in the human version of the same gene, which caused a severe autoimmune disorder known as IPEX. Two years later, Sakaguchi demonstrated that Foxp3 played a key role in producing a class of immune cells he had first identified in 1995.