The medicine Nobel Prize goes to 3 scientists for work on peripheral immune tolerance

"Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi won the Nobel Prize in medicine on Monday for their discoveries concerning peripheral immune tolerance. Brunkow is a senior program manager at the Institute for Systems Biology in Seattle. Ramsdell is a scientific adviser for Sonoma Biotherapeutics in San Francisco. Sakaguchi is a distinguished professor at the Immunology Frontier Research Center at Osaka University in Japan."

"The award is the first of the 2025 Nobel Prize announcements and was announced by a panel at the Karolinska Institute in Stockholm. Last year's prize was shared by Americans Victor Ambros and Gary Ruvkun for their discovery of microRNA, tiny bits of genetic material that serve as on and off switches inside cells that help control what the cells do and when they do it."

Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi won the Nobel Prize in medicine for discoveries about peripheral immune tolerance. Brunkow works at the Institute for Systems Biology in Seattle; Ramsdell is a scientific adviser for Sonoma Biotherapeutics in San Francisco; Sakaguchi is a professor at the Immunology Frontier Research Center at Osaka University. Peripheral immune tolerance prevents the immune system from attacking the body's own tissues. Sakaguchi made a key discovery in 1995; Brunkow and Ramsdell made another breakthrough in 2001; Sakaguchi linked their findings in 2003. The discoveries launched peripheral tolerance research and spurred development of cancer and autoimmune therapies, with several treatments in clinical trials.

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