Star quarterback Jackson left the game in the third quarter after being sacked by George Karlaftis and did not return as the Chiefs completed a 37-20 win. Asked about the two-time NFL MVP afterwards, Harbaugh was short on details but did not think it was a major concern. "There's nothing that looks like it's season-ending by any stretch for anybody," said Harbaugh, who saw four other starters - Roquan Smith, Marlon Humphrey, Nate Wiggins and Ronnie Stanley - also exit.