#homologous-recombination

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fromwww.nature.com
2 weeks ago

BCDX2CX3 and DX2CX3 complexes assemble and stabilize RAD51 filaments

Central to HR is the RAD51 recombinase, whose assembly into a nucleoprotein filament is governed by five RAD51 paralogs (RAD51B, RAD51C, RAD51D, XRCC2, XRCC3). Mutations in any of these proteins predispose individuals to multiple cancers or genetic disorders. These paralogs are thought to form two functionally separate complexes, BCDX2 and CX3, that act independently at different stages of HR.
Philosophy
fromAeon
2 months ago

Groundbreaking visuals capture how our bodies repair damaged DNA | Aeon Videos

Drew Berry creates striking biomedical animations that visualize microscopic biological processes like DNA repair, revealing intricate evolution-shaped cellular mechanisms.
Science
fromwww.nature.com
2 months ago

Author Correction: Structural insights into BCDX2 complex function in homologous recombination

Figure kymographs and several Source Data columns were duplicated during preparation; the figures and Source Data have been corrected and relabelled, with main conclusions unchanged.
fromenglish.elpais.com
5 months ago

Chinese scientists discover the DNA secret behind the naked mole-rat's astonishing longevity

There is an iron law in nature: the larger a species, the longer its members live. That's why whales outlive elephants, and elephants outlive lions. Very few animals defy this rule. Humans have circumvented it thanks to culture. But there is a small animal that laughs in its face. Given its size, the naked mole-rat (Heterocephalus glaber) shouldn't live more than two years, yet they often approach 40. What's more, they age healthily, without typical age-related diseases such as cancer, neurodegenerative disorders, or arthritis.
OMG science
Science
fromNature
5 months ago

Naked mole rats live for decades - genetic tweaks reveal insights into ageing

Four amino-acid substitutions in cGAS enable persistent enzyme activity that enhances DNA repair, supporting genomic maintenance and longevity in naked mole rats.
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