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#longevity #homologous-recombination #cgas #gene-editing #naked-mole-rat #crispr-delivery #lipid-nanoparticles
fromenglish.elpais.com
2 weeks ago

Chinese scientists discover the DNA secret behind the naked mole-rat's astonishing longevity

There is an iron law in nature: the larger a species, the longer its members live. That's why whales outlive elephants, and elephants outlive lions. Very few animals defy this rule. Humans have circumvented it thanks to culture. But there is a small animal that laughs in its face. Given its size, the naked mole-rat (Heterocephalus glaber) shouldn't live more than two years, yet they often approach 40. What's more, they age healthily, without typical age-related diseases such as cancer, neurodegenerative disorders, or arthritis.
OMG science
Science
fromNature
2 weeks ago

Naked mole rats live for decades - genetic tweaks reveal insights into ageing

Four amino-acid substitutions in cGAS enable persistent enzyme activity that enhances DNA repair, supporting genomic maintenance and longevity in naked mole rats.
Science
fromNews Center
1 month ago

CRISPR's Efficiency Triples With Spherical Nucleic Acid Delivery System - News Center

LNP-SNAs deliver complete CRISPR components into cells more safely and effectively, enhancing cellular uptake, reducing toxicity, and improving precise DNA-repair efficiency.
OMG science
fromNature
4 months ago

Rare 'ambidextrous' protein breaks rules of handedness

Scientists discovered an ambidextrous protein that can function in both left-handed and right-handed forms, potentially reflecting early life based on mirror-image molecules.
Cancer
fromwww.nature.com
5 months ago

Ku limits RNA-induced innate immunity to allow Alu-expansion in primates

Ku is crucial for human cells but not essential for mouse development, suggesting an evolved function in DNA repair and immunity.
Cancer
fromBuzzFeed
6 months ago

6 Signs You're Experiencing "Accelerated Aging," A Major Cancer Contributor

Aging reduces the body's DNA repair efficiency, increasing cancer risk.
Shortened telomeres contribute to genomic instability and cancer susceptibility.
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