Targeting Novel Molecular Mechanisms May Repair Damaged DNA - News CenterEZH2 protein dysregulates PARP1 activity, leading to impaired DNA repair in prostate cancer, informing potential targeted therapies for resistant cases.
Nucleosome flipping drives kinetic proofreading and processivity by SWR1 - NatureHistone variants like H2A.Z contribute to essential cellular processes including transcription and DNA repair through specialized nucleosome remodeling complexes.
This Shark Lives 400 Years. Its DNA May Explain Why.The Greenland shark's genome mapping reveals potential secrets to its remarkable 400-year lifespan and emphasizes the significance of genetic research in understanding longevity.
Tardigrade reaction to radiation may be useful for humansResearchers are mapping tardigrade DNA to understand radiation resistance, potentially leading to drugs that prevent or reverse radiation effects.
This Shark Lives 400 Years. Its DNA May Explain Why.The Greenland shark's genome mapping reveals potential secrets to its remarkable 400-year lifespan and emphasizes the significance of genetic research in understanding longevity.
Tardigrade reaction to radiation may be useful for humansResearchers are mapping tardigrade DNA to understand radiation resistance, potentially leading to drugs that prevent or reverse radiation effects.
Mechanism of BRCA1-BARD1 function in DNA end resection and DNA protection - NatureDNA end resection is a multi-step process vital for DNA repair, involving interplay between key proteins and complexes.
DNA strands show symmetry in damage tolerance but asymmetries in repair efficiencyDNA strands are replicated and repaired asymmetrically, influencing mutation rates.