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Data science
fromNature
2 weeks ago

AlphaFold hits 'next level': the AI tool now includes protein pairing

AlphaFold protein-structure database now includes 1.7 million homodimer predictions, expanding from individual protein structures to protein complexes for improved biological understanding.
fromwww.nature.com
4 weeks ago

BCDX2CX3 and DX2CX3 complexes assemble and stabilize RAD51 filaments

Central to HR is the RAD51 recombinase, whose assembly into a nucleoprotein filament is governed by five RAD51 paralogs (RAD51B, RAD51C, RAD51D, XRCC2, XRCC3). Mutations in any of these proteins predispose individuals to multiple cancers or genetic disorders. These paralogs are thought to form two functionally separate complexes, BCDX2 and CX3, that act independently at different stages of HR.
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