#cryoelectron-microscopy

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fromwww.nature.com
1 week ago

How short peptides disassemble tau fibrils in Alzheimer's disease

Reducing fibrous aggregates of the protein tau is a possible strategy for halting the progression of Alzheimer's disease (AD). The D-peptide D-TLKIVWC disassembles ultra-stable tau fibrils extracted from autopsied brains of individuals with AD into benign segments without any energy source except ambient thermal agitation.
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fromwww.nature.com
1 month ago

Protein-primed homopolymer synthesis by an antiviral reverse transcriptase

Our findings reveal that the Defense-associated reverse transcriptase (DRT9) system utilizes an RNA template to synthesize polydeoxyadenylate, serving as a pivotal defense mechanism against viral infections.
fromwww.nature.com
2 months ago

Molecular basis of SIFI activity in the integrated stress response

Essential insight gained from our research indicates that the E3 ubiquitin ligase SIFI plays a crucial role in integrating stress response mechanisms, ultimately helping maintain cellular health and stability.
fromwww.nature.com
3 months ago

Structures and mechanism of human mitochondrial pyruvate carrier

The study unveils six different cryo-EM structures of the human mitochondrial pyruvate carrier (MPC) showcasing its mechanisms in transporting pyruvate for cellular metabolism.
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