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#synthetic-chemistry #saxitoxin #total-synthesis #ch-functionalization #molecular-motors #redox-reactions
fromwww.nature.com
1 month ago

Scalable total synthesis of saxitoxin and related natural products

Saxitoxin (STX, 1), a potent neurotoxin from shellfish, first isolated in 19571, offers immense pharmaceutical potential due to its interaction with voltage-gated sodium channels2, that are ubiquitously present in all excitable cells of the central and periphperal nervous system3. Hundreds of synthetic studies towards this end have been disclosed thus far, yet, a fully modular and scalable approach to the family remains elusive4-12.
fromNature
2 months ago

Redox-powered autonomous directional C-C bond rotation under enzyme control - Nature

This paper presents a molecular motor that exhibits autonomous unidirectional rotation about a C-C single bond, driven by a cyclic redox reaction network involving concurrent biocatalytic oxidation and chemical reduction.
Science
Design
fromwww.nature.com
3 months ago

Complete computational design of high-efficiency Kemp elimination enzymes

The article discusses an advanced computational method for designing high-efficiency Kemp elimination enzymes without extensive mutational screening.
fromwww.nature.com
4 months ago
Productivity

Electricity-driven enzymatic dynamic kinetic oxidation

Electrochemistry is revitalizing synthetic chemistry through innovative enzyme applications, promising advancements in bioactive compound synthesis.
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