The article discusses the growing significance of electrochemistry in synthetic chemistry, highlighting the potential of repurposing natural enzymes through advanced chemical strategies. Techniques like directed evolution and photoenzymatic catalysis have expanded enzyme applications, yet the integration of electrochemistry with these enzymes has been largely restricted. The study reports a novel method involving thiamine-dependent enzymes and ferrocene-mediated electrocatalysis, which unlocks new kinetic oxidation processes for producing (S)-profens with exceptional enantiomeric excess, showcasing a robust electroenzymatic strategy that operates efficiently with minimal enzyme loading and demonstrates versatile mechanistic properties.
Electrochemistry is experiencing a resurgence in synthetic chemistry, emphasizing the promise of repurposing natural enzymes through innovative synthetic chemical strategies.
The integration of electrochemistry with enzymes has faced challenges, primarily limited to replicating established enzyme functions rather than discovering new reactivities.
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