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fromNature
4 days ago

Linear RAG scanning mediates editing of Ig variable region repertoires - Nature

Igh and Igk V(D)J recombination is orchestrated by the RAG1-RAG2 heterotetramer bound to a recombination centre formed around intronic enhancers and J segments of each locus. RAG cleaves robustly only paired gene segments flanked by bona fide RSSs with, respectively, 12-bp and 23-bp spacers, which must be properly aligned in parallel in the active sites of the two RAG1 proteins in the RAG complex.
Roam Research
Medicine
fromwww.nature.com
5 days ago

Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity

Somatic mutations in immune-regulatory genes may allow self-reactive lymphocytes to bypass tolerance checkpoints, contributing to autoimmune disease.
History
fromWorld History Encyclopedia
1 week ago

From smallpox to COVID: Vaccines that changed history.

Vaccination transformed public health by providing immunity against infectious diseases, significantly reducing mortality rates and eradicating smallpox.
OMG science
fromNature
2 weeks ago

'Treasure trove' of antiviral proteins could inspire powerful molecular tools

Bacteria possess a vast array of antiviral proteins, identified through machine-learning algorithms, which could lead to innovative biotechnologies.
Public health
fromNature
1 month ago

Capturing dynamic phage-pathogen coevolution by clinical surveillance - Nature

Phage-inducible chromosomal island-like elements (PLEs) in Vibrio cholerae provide defense against ICP1 phage predation, influencing pandemic strain evolution and disease severity through dynamic phage-bacteria interactions.
Science
fromNature
1 month ago

'Universal vaccine' protects mice against multiple pathogens

A nasal vaccine activating innate immunity provided mice broad, months-long protection against multiple respiratory viruses, bacteria, and allergens.
Science
fromwww.nature.com
1 month ago

Host control of persistent EpsteinBarr virus infection

Host non-genetic factors (HIV, immunosuppression, smoking) and genetic variation at MHC/HLA strongly influence blood Epstein-Barr virus (EBV) load during persistent infection.
Medicine
fromNature
2 months ago

A broadly protective antibody targeting gammaherpesvirus gB - Nature

Cong Sun, Chu Xie, and Bing‑Zhen Cheng contributed equally; correspondence to Cong Sun, Zheng Liu, or Mu‑Sheng Zeng; affiliations include Sun Yat‑sen Cancer Center and SUSTech.
Medicine
fromwww.theguardian.com
2 months ago

Positive thinking could boost immune response to vaccines, say scientists

Activating the brain's reward system (ventral tegmental area) through positive expectations enhances antibody responses to vaccination in humans.
Medicine
fromFuturism
1 month ago

Stanford's New "Universal Vaccine Formula" Nasal Spray Protects Mice Against Stunning Range of Diseases

A nasal-spray vaccine activates innate immunity to provide broad, temporary protection against diverse respiratory viruses, bacteria, and allergens in mice.
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