The molecule lithocholic acid, synthesized by gut bacteria, has been shown to extend lifespan in nematodes, fruit flies, and rejuvenate old mice, unlike previous unsubstantiated claims.
Nicholas Schork praised the thoroughness of the studies on lithocholic acid, stating that they went beyond many past claims about longevity benefits, which often lacked rigor.
Existing studies indicate calorie restriction can enhance lifespan across various animals; however, traditional methods like these often come with significant downsides like muscle loss and infection risks.
While promising, research on lithocholic acid's effects in humans is still lacking, and concerns about its potential toxicity at high doses remain unresolved.
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