Sickle cell disease, stemming from a single genetic mutation, leads to complex health challenges that have persisted for 70 years, complicating effective treatment.
The sickle-shaped cells caused by mutated hemoglobin can obstruct blood flow, resulting in severe pain crises, hospital visits, and significant risks like cardiac failure.
Research approaches to sickle cell disease are multifaceted, addressing the issue at various levels—from bone marrow mutation prevention to targeting cellular metabolism and immune responses.
Experts emphasize the interconnectedness of sickle cell impacts, prompting a holistic research strategy, as articulated by Marilyn Telen from Duke University.
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