Researchers fed 960 mice low-calorie diets or subjected them to regular bouts of fasting. While weight loss occurred, it was immune health that better explained increased lifespan. Overall resilience, encoded in the animals' genes, to food intake stress was also significant—more resilient animals lost less weight, maintained immune function, and lived longer.
This study suggests that the benefits of a low-calorie diet may not stem entirely from weight management but rather the immune health and genetic resilience of the mice. This offers new insights into the mechanisms by which caloric restriction may extend lifespan.
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