A study employing CRISPR gene editing revealed that inhibiting a specific gene involved in glucose metabolism rejuvenates brain stem cells, enhancing their ability to generate new neurons.
As aging diminishes brain stem cell activity, reducing the activity of a gene regulating glucose metabolism may restore their regenerative capabilities, according to the latest findings.
Neuroscientist Maura Boldrini highlighted that studies indicate aging affects brain metabolism, likely making it less efficient, and proposed that these findings could lead to new therapeutic avenues.
The ongoing debate about neurogenesis within the adult human brain raises questions around whether neural stem cells continue to produce new neurons into late adulthood.
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