Here's How Long You Should Smoke Brisket For Best Results - Tasting Table
Briefly

"The ideal time to smoke brisket is between 8 to 12 hours, depending on how hot you are cooking it. This can be argued until the end of time and really depends on your personal preference."
"Finding the right balance to impart flavor and lock in moisture is the key. If you prefer your brisket medium rare, you'll only need to smoke it until it reaches an internal temperature of 131 degrees Fahrenheit."
"To make smoked brisket, keep it at a steady heat of 250 degrees Fahrenheit. The low and slow method allows the meat and fat to break down properly, producing brisket that's tender inside and out."
Read at Tasting Table
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