"While multiple observational studies have demonstrated a relationship between low vitamin D and high risk for cardiovascular disease, few randomized controlled trials to date have evaluated the role of vitamin D supplementation on cardiovascular disease," said lead author Katharine W. Rainer, a resident physician at BIDMC. "Our study decisively showed that vitamin D had no effect on the markers of cardiovascular disease over the 2-year follow-up period, regardless of dose. These results reinforce evidence that vitamin D supplementation is not an effective intervention for cardiovascular disease prevention."
To evaluate the effect of vitamin D supplementation on the heart, researchers at BIDMC assessed whether higher doses of the vitamin reduced the presence of two specific proteins in the blood known to indicate cardiac injury and strain. The team's analysis of data from a double-blind, randomized trial - the gold standard of scientific testing that provides the most persuasive results - do not support the use of higher-dose vitamin D supplementation to reduce cardiovascular risk in adults with low blood levels of vitamin D.
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