Our study presents a comprehensive, spatially resolved single-cell transcriptomics atlas of brain ageing that elucidates cell-type-specific changes and spatial interactions across the lifespan.
The advent of high-throughput spatial omics technology offers new insights into the spatial context of neurodegenerative processes, which were previously obscured by a lack of resolution in studies.
By analyzing spatial transcriptomics data with advanced computational tools, we can now capture the intricate cell-cell interactions that characterize the ageing brain, especially in the context of rejuvenation.
Current research highlights a critical gap in understanding how local cell neighbourhoods change with age, which is essential for addressing cognitive decline and neurodegenerative diseases.
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