The findings published today in the Journal of the Obesity Society shows that there is a strong relationship between the increase in metabolic activity caused by once daily treatment with GLP-1 and the amount of weight lost.
Professor Donal O'Shea said the study challenges the main narrative about these newer treatments which is that they simply make you eat less, and that any action on energy burn is minimal.
The strength of the association is surprising given the relatively small numbers studied and suggests this increase in metabolic activity is a significant contributor to how these drugs work.
I hope the companies involved in the development of these treatments will examine this area in more detail because these are very expensive studies to carry out and we are very grateful to the Health Research Board and University College Dublin for supporting it.
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