#clinical-trial
#clinical-trial

New treatment improves outcomes for children with rare cancer

A new treatment combining anti-tumour drugs with chemotherapy shows promise in improving the chances of patients with neuroblastoma, a rare form of children's cancer.

The clinical trial found that patients who received the drug had better one-year progression-free survival rates compared to the control group. [ more ]

News Center

Skin Patch Improves Treatment for Pediatric Milk Allergies - News Center

Daily immunotherapy via dermal patch reduced risks in children with cow's milk allergy. [ more ]

www.theguardian.com

Breast cancer drug may help thousands more women than previously thought

Immunotherapy drug Keytruda could benefit more women with breast cancer

Study suggests Keytruda's effectiveness for different types of breast cancer [ more ]

News Center

Treating Skin Cancer Without Risking Transplanted Kidneys in Organ Recipients - News Center

Immunosuppressants and immunotherapy alone may not prevent organ rejection in kidney transplant recipients with skin cancer.

Transplant recipients face higher risk for skin cancer and limited treatment options due to potential rejection from traditional therapies. [ more ]

www.theguardian.com

First UK patients receive experimental messenger RNA cancer therapy

A new trial at Hammersmith hospital in west London is evaluating the safety and effectiveness of mRNA therapy in treating melanoma, lung cancer, and other solid tumors.

mRNA therapy works by presenting tumor markers to the patient's immune system, helping it recognize and fight cancer cells. [ more ]

Ars Technica

$158,000 ALS drug pulled from market after failing in large clinical trial

The drug Relyvrio, approved for ALS treatment, did not show benefits in a clinical trial and is being pulled from the market.

The FDA approved Relyvrio despite shaky data, and the drug's failure highlights the need for more effective ALS treatments. [ more ]

www.nytimes.com

A.L.S. Drug Relyvrio Fails Clinical Trial and May Be Withdrawn From the Market

FDA-approved ALS treatment Relyvrio failed a large clinical trial.

Results showed the treatment did not work better than a placebo. [ more ]

WIRED

The First Crispr Medicine Is Now Approved in the US

Casgevy uses Crispr technology to modify patients' cells and produce healthy hemoglobin.

Casgevy has shown promising results in a clinical trial, with 29 out of 31 patients being free of pain crises for at least a year. [ more ]

Chicago Tribune

Defying fate, woman with early-onset Alzheimer's gene joins new drug trial at Park Ridge hospital

Heather Mejia carried a rare genetic mutation for Dominantly Inherited Alzheimer's Disease and chose to participate in a clinical trial to study potential treatments for the disease.

Dominantly Inherited Alzheimer's Disease affects fewer than 1% of people with Alzheimer's and those with a family history have a 50% chance of inheriting the mutation.

The clinical trial at Advocate Lutheran General Hospital aims to delay the onset of symptoms for Dominantly Inherited Alzheimer's Disease. [ more ]

Chicago Tribune

Chicago

Afternoon Briefing: Woman with early-onset Alzheimer's gene joins drug trial at Park Ridge hospital

Developers of the Old Post Office faced challenges, including the need for running water.

Heather Mejia enrolled in a clinical trial for early onset Alzheimer's disease.

A fossil skeleton, known as Sue, was discovered on a property in South Dakota and sold for $7.6 million. [ more ]

SFGATE

Wine

Calif. researchers think they know why red wine causes headaches

Red wine headaches may be caused by the buildup of a toxin called acetaldehyde, triggered by the presence of quercetin in the wine.

Migraine sufferers and those prone to headaches are more likely to experience red wine headaches.

Grape varietals grown in high sun exposure have higher levels of quercetin, but fermentation and aging also play a role. [ more ]

moreclinical trial

Inverse

5 days ago

LSD - Yes, LSD - Shows Promising Results For Treating Anxiety

LSD, once marketed for various conditions, is now showing promise in treating general anxiety disorder with a single dose, as proven by a recent clinical trial. [ more ]

News Center

2 weeks ago

Cancer Drug Trial Provides Lessons for Future - News Center

Experimental cancer drug pazopanib ineffective in kidney cancer recurrence prevention post-surgery. [ more ]

www.theoaklandpress.com

A promising glioblastoma clinical trial: Cancer researchers say tumors dramatically shrunk

Novel cell therapy shrinks glioblastoma tumors dramatically

CAR-T cell therapy shows promising results in Phase 1 trial [ more ]

News Center

Evaluating Outcomes of Extended Thrombolytic Therapy for Ischemic Stroke - News Center

Thrombolytic therapy beyond 4.5 hours post-stroke doesn't improve outcomes.

Study tested tenecteplase in longer time frame for specific stroke cases. [ more ]

News Center

Cellular Therapy Increases Survival in Recurring B-cell Lymphoma - News Center

CAR T-cell therapy shows strong safety in treating B-cell lymphoma.

Personalized cellular therapy demonstrates improved overall survival in patients. [ more ]

BBC News

New eczema drug trial recruits Walsall patient, NHS trust says

A trial is underway for a new drug to treat eczema

The trial is looking at the drug LEO 138559 for the treatment of moderate to severe eczema [ more ]

www.independent.co.uk

UK news

Groundbreaking' UTI vaccine could stop infections for nine years

Oral spray vaccine can prevent recurring UTIs for up to nine years

54% of patients remained UTI-free for 9 years after using the vaccine. [ more ]

Nature

Data science

Interim analyses of a first-in-human phase 1/2 mRNA trial for propionic acidaemia - Nature

Propionic acidemia is a rare disorder with potentially life-threatening metabolic decompensation events.

mRNA-3927 therapy showed promising results in reducing the risk of metabolic decompensation events in participants. [ more ]

www.theguardian.com

Trial offers hope for millions that jab could prevent rheumatoid arthritis

Scientists have found that an existing drug for rheumatoid arthritis (RA) called abatacept could help prevent the onset of the disease.

The drug works by targeting the cause of inflammation, and a clinical trial found that it was effective in preventing RA in those at risk. [ more ]

New York Post

Vitamin D recommended levels should be 10x higher: new report

Vitamin D is critical for our health, including bone and teeth health, inflammation regulation, and immune system support.

The current US recommended dietary allowance of vitamin D may be too low, especially for people with heart problems.

Preliminary results from an ongoing clinical trial suggest that many people need significant levels of vitamin D supplements to reach optimal levels for heart health. [ more ]

www.theguardian.com

Gene therapy hailed as medical magic wand' for hereditary swelling disorder

A groundbreaking gene therapy has provided a permanent cure for patients with hereditary angioedema, a rare and debilitating disease.

Patients in the first human trial of the therapy experienced a dramatic improvement in their symptoms and were able to come off long-term medication. [ more ]

www.nytimes.com

Biogen Abandons Its Controversial Alzheimer's Drug Aduhelm

Biogen is abandoning its ownership rights to the Alzheimer's drug Aduhelm, after it failed to gain traction in the market.

The decision to abandon Aduhelm comes after the drug faced criticism for its weak evidence of efficacy, high price, and safety risks. [ more ]

MedCity News

Law

Ex-Pfizer Employee Convicted for Insider Trades Ahead of Positive Paxlovid Data

A former Pfizer employee has been convicted of insider trading after buying options in the company's stock prior to the announcement of positive Covid-19 drug data.

The employee, Amit Dagar, was a senior statistical program lead for the clinical trial of Pfizer's drug Paxlovid, which showed an 89% reduction in hospitalization or death compared to a placebo. [ more ]

www.nytimes.com

Wellness

What We Know About Multivitamins and Memory

Taking a daily multivitamin may benefit memory and cognitive function in older adults.

Experts caution that the benefits are small and may not translate to significant improvements in daily life. [ more ]

National Institute of Mental Health (NIMH)

4 months ago

Mental health

Magnetic Seizure Therapy as Effective as Electroconvulsive Therapy for Treating Depression

Major depression affects millions of adults in the US and current treatments don't work for everyone.

Magnetic seizure therapy (MST) is being studied as a potential treatment with fewer memory and cognitive side effects than electroconvulsive therapy (ECT). [ more ]

Inverse

Mental health

Novel Brain Implant May Give Cognitive Boost For Common Brain Injury

Advancements in brain implants are providing therapeutic answers for patients with traumatic brain injuries.

A small clinical trial showed that deep-brain stimulation with implanted electrodes led to cognitive improvement in individuals with brain injuries. [ more ]

The Atlantic