This study investigates the emergence of stem-like CD8+ T cells critical for durable immunity against chronic viral infections and cancer, underlining their significance in PD-1 mediated immunotherapy.
We identified that stem-like CD8+ T cells develop as early as day 5 during chronic viral infection, indicating that their differentiation is independent of the immune response outcome.
The presence of PD-1+ TCF-1+ TOX+ stem-like CD8+ T cells suggests a unique adaptive mechanism, enabling longevity of T cell responses despite persistent antigen exposure.
Understanding the differentiation pathway of these stem-like CD8+ T cells could significantly enhance strategies for immunotherapy, particularly in contexts of chronic infections and cancer treatment.
Collection
[
|
...
]