Emergency services were called at about 10:45 GMT to reports of a fight on the bridge, where a man was critically injured from stab wounds.
The Met Police confirmed three people have been arrested on suspicion of attempted murder, and another for affray following the incident on Westminster Bridge.
The incident is not being treated as terror-related, and infrastructure around Westminster Bridge is closed while investigations are ongoing.
Buses including 11, 12, 148, 159, and 453 are currently on diversion due to the closures around Westminster Bridge as police investigate.
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