Ageing is associated with increased proportions of my-HSCs, resulting in decreased lymphopoiesis and increased myelopoiesis.
Here we demonstrate that antibody-mediated depletion of my-HSCs in aged mice restores characteristic features of a more youthful immune system.
#hematopoietic-stem-cells #immune-system-aging #antibody-depletion #immune-response #age-related-changes
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