#hematopoietic-stem-cells

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#clonal-hematopoiesis #aging #inflammation #blood-malignancy #vexas #uba1 #necroptosis #macrophage-inflammation
Medicine
fromNature
4 days ago

Human haematopoietic stem cells remember inflammatory stress - Nature

Inflammation-driven heterogeneity in human HSCs contributes to age-related functional decline and clonal hematopoiesis, influencing clone expansion and malignancy risk.
fromwww.nature.com
6 months ago

Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome

Somatically acquired mutations in the E1 ubiquitin-activating enzyme UBA1 within hematopoietic stem and progenitor cells (HSPCs) were recently identified as the cause of the adult-onset autoinflammatory syndrome VEXAS (vacuoles, E1 enzyme, X linked, autoinflammatory, somatic)1. UBA1 mutations in VEXAS lead to clonal expansion within the HSPC and myeloid, but not lymphoid, compartments. Despite its severity and prevalence, the mechanisms whereby UBA1 mutations cause multiorgan autoinflammation and hematologic disease are unknown.
Health
fromwww.nature.com
9 months ago

Therapeutic genetic restoration through allogeneic brain microglia replacement

A brain-restricted microglia replacement approach avoids myeloablation and enhances therapy for lysosomal storage diseases.
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