#schizophrenia

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#muscarinic-receptors

New schizophrenia drug could treat Alzheimer's disease

A new era in psychiatric medicine is suggested by the approval of innovative drugs, though not all trials yield positive results.

Revolutionary drug for schizophrenia wins US approval

KarXT represents a groundbreaking schizophrenia treatment with a unique mechanism of action that may improve patient outcomes and tolerability compared to existing therapies.

For the first time in decades, we have a new kind of schizophrenia drug

Cobenfy is a groundbreaking drug that targets muscarinic receptors, potentially offering a new treatment avenue for schizophrenia sufferers.

New schizophrenia drug could treat Alzheimer's disease

A new era in psychiatric medicine is suggested by the approval of innovative drugs, though not all trials yield positive results.

Revolutionary drug for schizophrenia wins US approval

KarXT represents a groundbreaking schizophrenia treatment with a unique mechanism of action that may improve patient outcomes and tolerability compared to existing therapies.

For the first time in decades, we have a new kind of schizophrenia drug

Cobenfy is a groundbreaking drug that targets muscarinic receptors, potentially offering a new treatment avenue for schizophrenia sufferers.
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#mental-illness

People Are Opening Up About What It's Like To Have Schizophrenia, And It's Incredibly Interesting

Understanding schizophrenia requires empathy, as each individual's experience with symptoms like hallucinations and delusions varies significantly.

Colorado man found guilty of murder in supermarket shooting that killed 10

Ahmad Alissa was found guilty of murder despite his claim of insanity, as jurors assessed his sanity during the attack.

Killer detained indefinitely for stabbing pensioner on mobility scooter while in 'Hunger Games' delusion

Lee Byer, suffering from paranoid schizophrenia, detained indefinitely after fatally stabbing Thomas O'Halloran with delusional belief of being in a Hunger Games scenario.

I am a psychiatrist covering Bondi. We need to invest in mental health services, not stigmatise people | Kamran Ahmed

Schizophrenia is not directly linked to mass attacks; most individuals with this condition do not commit violent offenses.

Facebook Live: Understanding Schizophrenia

Overview
In recognition of National Mental Health Awareness Month, the National Institute of Mental Health (NIMH) is hosting a Facebook Live event on schizophrenia.Schizophrenia is a serious mental illness that affects how a person thinks, feels, and behaves.It's important to know how to recognize the symptoms of schizophrenia and seek help as early as possible.

Jim Gordon, Top Rock Drummer With a Troubled Life, Dies at 77

Jim Gordon, a talented but troubled drummer who was ubiquitous in the recording studios of the 1960s and '70s and who, as a member of Eric Clapton's band Derek and the Dominos, helped write the romantic ballad Layla but who suffered from schizophrenia and spent nearly 40 years in prison, convicted of murdering his mother died on Monday in a prison medical facility in Vacaville, Calif.

People Are Opening Up About What It's Like To Have Schizophrenia, And It's Incredibly Interesting

Understanding schizophrenia requires empathy, as each individual's experience with symptoms like hallucinations and delusions varies significantly.

Colorado man found guilty of murder in supermarket shooting that killed 10

Ahmad Alissa was found guilty of murder despite his claim of insanity, as jurors assessed his sanity during the attack.

Killer detained indefinitely for stabbing pensioner on mobility scooter while in 'Hunger Games' delusion

Lee Byer, suffering from paranoid schizophrenia, detained indefinitely after fatally stabbing Thomas O'Halloran with delusional belief of being in a Hunger Games scenario.

I am a psychiatrist covering Bondi. We need to invest in mental health services, not stigmatise people | Kamran Ahmed

Schizophrenia is not directly linked to mass attacks; most individuals with this condition do not commit violent offenses.

Facebook Live: Understanding Schizophrenia

Overview
In recognition of National Mental Health Awareness Month, the National Institute of Mental Health (NIMH) is hosting a Facebook Live event on schizophrenia.Schizophrenia is a serious mental illness that affects how a person thinks, feels, and behaves.It's important to know how to recognize the symptoms of schizophrenia and seek help as early as possible.

Jim Gordon, Top Rock Drummer With a Troubled Life, Dies at 77

Jim Gordon, a talented but troubled drummer who was ubiquitous in the recording studios of the 1960s and '70s and who, as a member of Eric Clapton's band Derek and the Dominos, helped write the romantic ballad Layla but who suffered from schizophrenia and spent nearly 40 years in prison, convicted of murdering his mother died on Monday in a prison medical facility in Vacaville, Calif.
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#mental-health

A First Episode of Mental Illness

Understanding the subtle signs of psychiatric illness is essential for early intervention and support.

A new kind of drug for schizophrenia promises fewer side effects

The FDA has approved Cobenfy, a new schizophrenia drug promising fewer side effects than existing medications.

I admitted my teen to a psychiatric ward. With time apart, I realized I also needed to take care of myself.

Navigating the challenges of parenting a child with schizophrenia requires support for both the child and the parent's well-being.

F.D.A. Approves the First New Schizophrenia Drug in Decades

Cobenfy is the first new antipsychotic in decades, aiming to treat schizophrenia without severe side effects like weight gain.

I Wish I Had Been Taught About Schizophrenia

Mental illness can affect anyone, regardless of perceived strength or success.

How Do We Know What Illness a Mentally Ill Person Has?

Schizophrenia must be carefully distinguished from other psychotic illnesses to ensure effective treatment.

A First Episode of Mental Illness

Understanding the subtle signs of psychiatric illness is essential for early intervention and support.

A new kind of drug for schizophrenia promises fewer side effects

The FDA has approved Cobenfy, a new schizophrenia drug promising fewer side effects than existing medications.

I admitted my teen to a psychiatric ward. With time apart, I realized I also needed to take care of myself.

Navigating the challenges of parenting a child with schizophrenia requires support for both the child and the parent's well-being.

F.D.A. Approves the First New Schizophrenia Drug in Decades

Cobenfy is the first new antipsychotic in decades, aiming to treat schizophrenia without severe side effects like weight gain.

I Wish I Had Been Taught About Schizophrenia

Mental illness can affect anyone, regardless of perceived strength or success.

How Do We Know What Illness a Mentally Ill Person Has?

Schizophrenia must be carefully distinguished from other psychotic illnesses to ensure effective treatment.
moremental-health

FDA Approves the First New Schizophrenia Drug in Decades

Cobenfy is the first new schizophrenia treatment approved in 30 years, targeting the cholinergic system instead of dopamine.

Opinion | Doctors, Not Judges, Should Decide When to Treat Patients Without Their Consent

Treating patients with untreated schizophrenia involuntarily might be necessary to ensure their well-being even if it requires court orders.

Serious care failings were a factor in son killing his father, coroner in Wales rules

Serious failings in care led to a tragic outcome for a man with schizophrenia, highlighting inadequacies in mental health services.
#philip-theophilou

Convicted killer who escaped from mental health unit in Homerton detained in Croydon after four-day manhunt

Theophilou, a convicted killer, absconded from a mental health facility in London and sparked a police manhunt.
Theophilou had previously stabbed his neighbor to death in 2004 and was found in a hospital in south London.

Man who stabbed neighbour to death found after absconding from mental health facility

The killer who absconded from a mental health facility in London has been found after a CCTV review.
Philip Theophilou, who killed his neighbor in 2004, was returned to the facility after being discovered in a hospital.

Convicted killer who escaped from mental health unit in Homerton detained in Croydon after four-day manhunt

Theophilou, a convicted killer, absconded from a mental health facility in London and sparked a police manhunt.
Theophilou had previously stabbed his neighbor to death in 2004 and was found in a hospital in south London.

Man who stabbed neighbour to death found after absconding from mental health facility

The killer who absconded from a mental health facility in London has been found after a CCTV review.
Philip Theophilou, who killed his neighbor in 2004, was returned to the facility after being discovered in a hospital.
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Melvin Way, Outsider Artist Who Depicted Inner Mysteries, Dies at 70

Melvin Way's hallucinatory diagrams gained recognition in the art world despite his challenging circumstances.
Mr. Way's drawings were intricate and diverse, depicting a wide range of subjects from disease cures to drug recipes.

Man who fatally shot 2 teens in a California movie theater is sentenced to life without parole

Man sentenced to life in prison for shooting teens at movie theater
Jimenez diagnosed with schizophrenia and stopped taking medication

Peter McGuffin obituary

Importance of gene-environment interplay in psychiatric disorders
Challenging assumptions about depression and genetic risk

Are your friends talking about you? The truth about paranoia and why it's higher than ever

Clinical trial of psychological therapy for schizophrenia patients with delusions and hallucinations
Challenges of working with a patient who believes in government conspiracies

Dr. Drew warns of 'extremely worrisome' marijuana study findings that link cannabis use with psychotic states

Marijuana use is associated with a higher risk of developing schizophrenia or bipolar disorder, especially for teens and young adults.
The concentration of cannabis in states where it is legal for recreational use is approaching 100%, making it a different and more potent drug.

A New Drug Compound Shows Promise for Schizophrenia

KarXT, developed by Karuna Therapeutics, is a promising new treatment for schizophrenia that targets a different brain chemical than most existing treatments.
In a study involving 252 people with schizophrenia, those taking KarXT showed fewer extremes of positive and negative symptoms compared to those on a placebo.

New Tool Accurately Predicts Suicide Risk in SMI

A brief scalable suicide risk assessment tool accurately predicts suicide risk in patients with serious mental illness (SMI), a new population-based study shows.The 17-question Oxford Mental Illness and Suicide Tool (OxMIS) assessment is designed to predict 12-month suicide risk in people with schizophrenia spectrum disorders and bipolar disorder based on risk factors such as familial traits, antisocial traits, and information about self-harm.

Underused Med May Curb Schizophrenia's 'Most Dreaded Outcome'

The antipsychotic clozapine appears to guard against suicide for patients with treatment-resistant schizophrenia, results of an autopsy study suggest.Investigators reviewed over 53,000 autopsy records, including over 600 from individuals whose autopsies revealed the presence of the antipsychotics clozapine or olanzapine, and found that those who took clozapine were significantly less likely to have died by suicide compared to their counterparts who were taking olanzapine.

Can a Machine Know That We Know What It Knows?

Mind reading is common among us humans.Not in the ways that psychics claim to do it, by gaining access to the warm streams of consciousness that fill every individual's experience, or in the ways that mentalists claim to do it, by pulling a thought out of your head at will.Everyday mind reading is more subtle: We take in people's faces and movements, listen to their words and then decide or intuit what might be going on in their heads.

COVID in Pregnancy May Affect Boys' Neurodevelopment: Study

Boys born to mothers infected with SARS‐CoV‐2 during pregnancy may be more likely to receive a diagnosis of a neurodevelopmental disorder by age 12 months, according to new research.Andrea G. Edlow, MD, MSc, with Massachusetts General Hospital and Harvard Medical School in Boston, and colleagues examined data from 18,355 births between March 1, 2020, and May 31, 2021 at eight hospitals across two health systems in Massachusetts.

New Schizophrenia Genes Identified

Scientists have identified two new genes linked to schizophrenia and discovered that a third gene previously known to be involved in the disorder may also play a role in autism.The genes were identified through a meta-analysis comparing gene sequences of 35,828 people with schizophrenia to 107,877 people without the condition.
#years

Jim Gordon, a famed session drummer who killed mother, dies

LOS ANGELES Jim Gordon, the famed session drummer who backed Eric Clapton and The Beach Boys before being diagnosed with schizophrenia and going to prison for killing his mother, has died.He was 77. Gordon died Monday at the California Medical Facility in Vacaville, the state Department of Corrections and Rehabilitation confirmed Thursday.

Jim Gordon, drummer on Eric Clapton hits who was convicted of killing mother, dead at 77

Jim Gordon, who drummed with Eric Clapton and is credited with co-writing the mega-hit "Layla" years before he was convicted of killing his own mother, died Monday at age 77.The musician died of natural causes at California Medical Facility, a state prison hospital in Vacaville, Calif., according to Variety.

The battle to boost our deep sleep and help stop dementia

Tonight, and almost every night, something amazing will happen inside your brain.As you turn off the light switch and fall asleep, you will be switching on the neurological equivalent of a dishwasher deep-clean cycle.First, the activity of billions of brain cells will begin to synchronise, and oscillate between bursts of excitation and rest.

Psychedelics Are a Promising Therapy, but They Can Be Dangerous for Some

When Dr. Charles Nemeroff first met his patient, the 32-year-old woman had already been to see several psychiatrists.Initially, the woman, whose identity has been concealed to protect her privacy, had experienced paranoid and racing thoughts, insisting there were listening devices in her phone and that people were watching her; she even sold her home in an attempt to get away from them.

The first wiring map of an insect's brain hints at incredible complexity

What looks like a pin-headed critter on the right is actually a larval version of the fruit fly on the left.Both have remarkably complex brains, scientists say, with different regions devoted to decision-making, learning and navigation.Ed Reschke/Getty Images Scientists have created the first detailed wiring diagram of an insect brain.

I found out my mum had schizophrenia when I was 14. Here's what I wish I'd known | Elfy Scott

When I was told that my mum was living with schizophrenia by my school counsellor, when I was about 14 I had almost no concept of what that really meant.All I knew for sure was that it felt dark, scary and taboo.In other words, my understanding of complex mental health was almost entirely defined by the stigma that surrounds it.

Jim Gordon, a famed session drummer who killed mother, dies

LOS ANGELES Jim Gordon, the famed session drummer who backed Eric Clapton and The Beach Boys before being diagnosed with schizophrenia and going to prison for killing his mother, has died.He was 77. Gordon died Monday at the California Medical Facility in Vacaville, the state Department of Corrections and Rehabilitation confirmed Thursday.

Jim Gordon, drummer on Eric Clapton hits who was convicted of killing mother, dead at 77

Jim Gordon, who drummed with Eric Clapton and is credited with co-writing the mega-hit "Layla" years before he was convicted of killing his own mother, died Monday at age 77.The musician died of natural causes at California Medical Facility, a state prison hospital in Vacaville, Calif., according to Variety.

The battle to boost our deep sleep and help stop dementia

Tonight, and almost every night, something amazing will happen inside your brain.As you turn off the light switch and fall asleep, you will be switching on the neurological equivalent of a dishwasher deep-clean cycle.First, the activity of billions of brain cells will begin to synchronise, and oscillate between bursts of excitation and rest.

Psychedelics Are a Promising Therapy, but They Can Be Dangerous for Some

When Dr. Charles Nemeroff first met his patient, the 32-year-old woman had already been to see several psychiatrists.Initially, the woman, whose identity has been concealed to protect her privacy, had experienced paranoid and racing thoughts, insisting there were listening devices in her phone and that people were watching her; she even sold her home in an attempt to get away from them.

The first wiring map of an insect's brain hints at incredible complexity

What looks like a pin-headed critter on the right is actually a larval version of the fruit fly on the left.Both have remarkably complex brains, scientists say, with different regions devoted to decision-making, learning and navigation.Ed Reschke/Getty Images Scientists have created the first detailed wiring diagram of an insect brain.

I found out my mum had schizophrenia when I was 14. Here's what I wish I'd known | Elfy Scott

When I was told that my mum was living with schizophrenia by my school counsellor, when I was about 14 I had almost no concept of what that really meant.All I knew for sure was that it felt dark, scary and taboo.In other words, my understanding of complex mental health was almost entirely defined by the stigma that surrounds it.
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Perinatal Interpersonal Violence Risk Higher in Schizophrenia

Pregnant and postpartum patients with schizophrenia are three times more likely to experience interpersonal violence, compared with those without schizophrenia, a new study suggests.In a population-based cohort study that included almost 2 million participants, 3.1% of patients with schizophrenia had an emergency department (ED) visit for interpersonal violence during pregnancy or the first postpartum year, compared with 0.4% of those without schizophrenia.
#people

Alameda County DA forms mental health advisory group

By Olivia Wynkoop | Bay City News Foundation The Alameda County District Attorney's office is creating a countywide coalition of mental health activists and parents to advise on mental health issues in the criminal justice system.The 26-member District Attorney's Mental Health Commission will advise the office on how to better respond to criminal justice cases involving people with serious mental illnesses.

National Guard Sent To Help Trapped Residents In San Bernardino Mountains

National Guard Going Door-To-Door To Help Those Possibly Trapped In San Bernardino Mountains
California National Guard personnel have arrived in the San Bernardino Mountains.They're there to help rescue residents who have been trapped in their homes for days by the recent heavy snowfall.Hunger Strike Continues In Protest Of Two Kern County Detention Centers
A hunger strike at two California immigration detention centers in Kern County is entering its third week.

Failed asylum seeker detained in hospital following dreadful' village murder

A failed asylum seeker who killed an elderly woman in a picturesque North Yorkshire village has been detained indefinitely at a secure hospital by a judge who said it was an act of appalling brutality.Shahin Darvish-Narenjbon, 34, was befriended by 87-year-old Brenda Blainey when she met him in a Leeds restaurant and he went to live with her in the tourist village of Thornton-le-Dale, where she treated him like a grandson, Judge Rodney Jameson KC said on Wednesday.

Kids Born in June Have Some Massive Advantages

Babies born in June are bigger, taller, optimistic, and more likely to win Nobel Prizes.For spring babies, who are more prone to depression, early puberty, and occasionally fascism, this adds insult to injury.But for everyone else, it signals a positive shift in the science of seasonality for summer babies, who have a lot going for them.

ChatGPT Can do a Corporate Lobbyist's Job, Study Determines

An AI researcher at Stanford University has drafted a paper showing that OpenAI's new chatbot, ChatGPT, has an aptitude for corporate lobbying.In his paper, John J. Nay argued that as language models continue to improve, so will their performance on corporate lobbying tasks.It suggests a future where corporate lobbyists, which make up the largest group of lobbyists on the Hill and spend billions of dollars a year influencing political decision-makers, will be able to automate the process of drafting legislation and sending letters to the government.

Kids Born In February Have Some Massive Advantages

Legend has it that babies with February births have been getting screwed out of a full birth month ever since the ancient Roman emperor Augustus Caesar stole a day from February to add it to August.Nonetheless, studies suggest that parents of February babies can rest assured that their kids have more to celebrate than fear about their birth month.

Alameda County DA forms mental health advisory group

By Olivia Wynkoop | Bay City News Foundation The Alameda County District Attorney's office is creating a countywide coalition of mental health activists and parents to advise on mental health issues in the criminal justice system.The 26-member District Attorney's Mental Health Commission will advise the office on how to better respond to criminal justice cases involving people with serious mental illnesses.

National Guard Sent To Help Trapped Residents In San Bernardino Mountains

National Guard Going Door-To-Door To Help Those Possibly Trapped In San Bernardino Mountains
California National Guard personnel have arrived in the San Bernardino Mountains.They're there to help rescue residents who have been trapped in their homes for days by the recent heavy snowfall.Hunger Strike Continues In Protest Of Two Kern County Detention Centers
A hunger strike at two California immigration detention centers in Kern County is entering its third week.

Failed asylum seeker detained in hospital following dreadful' village murder

A failed asylum seeker who killed an elderly woman in a picturesque North Yorkshire village has been detained indefinitely at a secure hospital by a judge who said it was an act of appalling brutality.Shahin Darvish-Narenjbon, 34, was befriended by 87-year-old Brenda Blainey when she met him in a Leeds restaurant and he went to live with her in the tourist village of Thornton-le-Dale, where she treated him like a grandson, Judge Rodney Jameson KC said on Wednesday.

Kids Born in June Have Some Massive Advantages

Babies born in June are bigger, taller, optimistic, and more likely to win Nobel Prizes.For spring babies, who are more prone to depression, early puberty, and occasionally fascism, this adds insult to injury.But for everyone else, it signals a positive shift in the science of seasonality for summer babies, who have a lot going for them.

ChatGPT Can do a Corporate Lobbyist's Job, Study Determines

An AI researcher at Stanford University has drafted a paper showing that OpenAI's new chatbot, ChatGPT, has an aptitude for corporate lobbying.In his paper, John J. Nay argued that as language models continue to improve, so will their performance on corporate lobbying tasks.It suggests a future where corporate lobbyists, which make up the largest group of lobbyists on the Hill and spend billions of dollars a year influencing political decision-makers, will be able to automate the process of drafting legislation and sending letters to the government.

Kids Born In February Have Some Massive Advantages

Legend has it that babies with February births have been getting screwed out of a full birth month ever since the ancient Roman emperor Augustus Caesar stole a day from February to add it to August.Nonetheless, studies suggest that parents of February babies can rest assured that their kids have more to celebrate than fear about their birth month.
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Dissociative Identity Disorder: Fad or Fact?

PARIS - The 2023 Encéphale Congress devoted a session to dissociative identity disorder (DID).It's a fascinating condition that has been depicted in countless movies and TV shows.And while it may be the key to success at the box office and in the ratings, DID nonetheless remains a controversial topic within the psychiatric community.

The All Seeing Eye: Richard Cook on Wayne Shorter's Blue Note albums - The Wire

March 2023 Top row (left to right): Night Dreamer (1964); JuJu (1965); The All Seeing Eye (1966).Bottom row (left to right): Speak No Evil (1966); Adam's Apple (1966); Schizophrenia (1969)

Wayne Shorter died on 2 March 2023, aged 89.Read Richard Cook's survey of the saxophonist's Blue Note albums from Night Dreamer to Schizophrenia in The Wire 11, January 1985 in our online library for free.

New Insight Into Preventing Antipsychotic-Induced Weight Gain

New research may help physicians avoid the widespread problem of antipsychotic-induced weight gain and changes in metabolic parameters in patients with acute schizophrenia.In the first dose-response meta-analysis focusing on antipsychotic-induced weight gain, researchers provide data on the trajectory of this risk associated with individual agents.

No Benefit of Long-Acting Antipsychotics in Schizophrenia?

In patients with early-phase schizophrenia, long-acting injectable antipsychotics (LAIs) provide no benefit over oral antipsychotics (OAs) in preventing discontinuation of antipsychotic treatment, new research suggests.In a multicountry, randomized, open-label study of more than 500 adults with schizophrenia, participants received either LAI paliperidone, LAI aripiprazole, or the respective oral formulation of these antipsychotics.

Psychiatric Illnesses Share Common Brain Network

A network of neural connections is linked to six psychiatric disorders: schizophrenia, bipolar disorder (BD), depression, addiction, obsessive-compulsive disorder (OCD), and anxiety, new research shows.Investigators used coordinate and lesion network mapping to assess whether there was a shared brain network common to multiple psychiatric disorders.

Lipid Signature May Flag Schizophrenia

A specific lipid profile can identify patients with schizophrenia, possibly paving the way for the development of the first clinically useful diagnostic test for a severe psychiatric illness, new research suggests.Although such a test remains a long way off, investigators said, the identification of the unique lipid signature is a critical first step.

Sleep Abnormalities Common In All Stages of Psychosis

Sleep disturbances are consistently high throughout the course of psychosis - with later stages associated with distinctive brain wave activity during sleep, a new review and meta-analysis shows.For example, compared with their healthy peers, participants in a chronic psychosis stage had reduced density, amplitude, and duration of spindles - or bursts of brainwave activity during sleep identified by electroencephalography (EEG).

Novel Antipsychotic 'Encouraging' for Resistant Schizophrenia

The experimental antipsychotic evenamide is associated with reduced severity of symptoms when added to an existing antipsychotic in treatment-resistant schizophrenia (TRS), new research suggests.The topline results from an exploratory study, which were released by the developer Newron Pharmaceuticals, are "very encouraging," Stephen R. Marder, MD, professor of psychiatry and biobehavioral sciences at the University of California Los Angeles (UCLA), said in a company news release.

Dopamine Dysregulation a Causative Culprit in Schizophrenia?

A genetic postmortem analysis of the brains of patients with schizophrenia suggests dysfunction of dopamine receptors in the caudate nucleus may cause the disorder.Investigators identified a mechanism on the dopamine receptor, known as the autoreceptor, which regulates how much dopamine is released from the presynaptic neuron.
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