"AMP SCZ is a high-profile public-private partnership in schizophrenia. The study is focused on developing and implementing a set of tools to create multimodal algorithms that distinguish trajectories and endpoints in individuals at risk for developing schizophrenia such as conversion, remission, and unremitted symptoms. Valid biomarkers, clinical assessment tools, and algorithms would have a significant positive impact on clinical trials of novel interventions for this relatively understudied population."
"The AMP SCZ initiative is leveraging a large investment from NIMH and public-private partners to conduct the most comprehensive, longitudinal study in individuals at risk for schizophrenia. Over 2,617 study participants have been recruited into the study. Study participants will be assessed longitudinally for up to 24 months. Measures include clinical assessments, cognitive, neurophysiology, neuroimaging, genetics and fluid biomarkers, speech and facial expression, and digital assessments."
"All participants have completed baseline to month 2 timepoints but the collection of the full data set will not be completed until June 2027. A reissue of the Data Processing Analysis Coordination Center is needed to ensure continuity of data processing, real-time quality assurance/quality control pipelines, and completion of the primary analyses of the full data set."
AMP SCZ aims to develop multimodal tools and algorithms to distinguish conversion, remission, and persistent symptoms among individuals at risk for schizophrenia. The initiative leverages substantial NIMH and public-private funding to conduct the most comprehensive longitudinal assessment of at-risk individuals, recruiting over 2,617 participants. Participants undergo up to 24 months of follow-up with clinical, cognitive, neurophysiology, neuroimaging, genetic, fluid biomarker, speech, facial expression, and digital assessments. All participants completed baseline to month 2 timepoints, but full data collection extends through June 2027. A reissued Data Processing, Analysis and Coordination Center is required to maintain processing continuity, real-time QA/QC, and complete primary analyses. All generated data will be shared as a public resource.
Read at National Institute of Mental Health (NIMH)
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