#antiretroviral-therapy

#antiretroviral-therapy

On that sunny March morning, in a small health center in Lobamba, a rural area of Eswatini, this 32-year-old sex worker has just become one of the first people in the world to receive lenacapavir, a drug that, administered twice a year, offers nearly 100% protection against HIV.

Kelly Chibale describes the drug discovery process as a fairy-tale quest, stating, 'It doesn't mean that there aren't surprises or miracles. They do happen, but you have to kiss many frogs before you meet the prince.' This metaphor illustrates the challenges and unpredictability in finding effective medicines.

Congress has kept key drug assistance funding at $900.3 million annually since 2014. New enrollments for state programs jumped 30% from 2022 to 2024, in part because states cut off pandemic-era Medicaid assistance. As of January, at least 18 states have pulled back their Ryan White AIDS Drug Assistance Programs, known as ADAPs, in some way.

For more than a decade, doctors and researchers have announced that a handful of people around the world have been cured of HIV. Each of these patients has experienced long-term viral control - in some cases for over a decade - without antiretroviral therapy (ART), as AIDSMap notes, though some doctors describe them as being in "remission." While the patients have shown no signs of HIV since stopping ART, at least some uncertainty remains as to whether the virus could eventually rebound in them.

Black people made up 48 percent of new HIV diagnoses in the South, but only 21 percent of PrEP users in the South; in the Midwest, Black people made up 48 percent of new HIV diagnoses, but only 12 percent of PrEP users. This regional disparity demonstrates the significant gap between HIV burden and preventive medication access among Black populations across different areas of the country.

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