The common idea that sulfites cause headaches from red wine lacks strong evidence, as other foods containing sulfites do not elicit the same reaction.
While tannin has been thought to be responsible, its presence in tea and chocolate, which don’t cause headaches, suggests other phenolic compounds may be culprits.
Biogenic amines are sometimes blamed for headaches, but their presence in wine is not at levels that would typically lead to such symptoms.
The true cause of red wine headaches may hinge on lesser-known phenolic compounds that are prevalent in red wines but absent in whites.
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