The 49ers have struggled mightily without Bosa and Williams, arguably two of the best players in the league at their positions and undoubtedly two of the most difficult to replace on the team. Since Williams arrived via trade in 2020, San Francisco is 49-28 when he plays and 3-8 when he doesn't. Since Bosa arrived in 2019, the Niners are 62-28 when he plays and 5-12 when he doesn't.
Jaylon Moore will make his third straight start in place of Williams. Sam Okuayinonu and Yetur Gross-Matos are expected to fill the void for Bosa. While the 49ers again will be without key starters, they do have a couple of important players back to full strength which may help them in their upcoming match.
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