The Niners have suffered several injuries to key players this season, and Aiyuk's torn ACL adds to that growing list of setbacks for the team.
Kyle Shanahan expressed initial hope that Aiyuk's injury would not be as severe as it turned out to be, saying they were 'praying' for better news.
Aiyuk's absence will impact his chase for back-to-back 1,000-yard seasons, having recorded significantly lower stats this year before his injury.
Following the injury, the 49ers are left to adapt without a key contributor, as Aiyuk was not only an important wide receiver but a recently signed extension.
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