Safety Talanoa Hufanga will not play against the Patriots due to an ankle injury, despite recently returning from knee reconstruction and making a season debut.
After observing warmups, Hufanga did not attempt to test his ankle, with rookie Malik Mustapha potentially starting in his position if George Odum isn’t returned.
The 49ers face significant injury challenges as key players including Deebo Samuel, Trent Williams, and various others remain questionable or inactive.
The team’s injury list continues to grow, with several players affected by illnesses, highlighting the 49ers’ challenging situation ahead of their game.
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