The 49ers are optimistic about their lineup against the Patriots, as key players Brock Purdy and George Kittle return from injuries, strengthening the team's chances.
Coach Kyle Shanahan has expressed hope for Deebo Samuel's appearance this Sunday, especially after he was ruled out early for Week 3 due to a calf strain.
With significant injuries to players like Javon Hargrave and Curtis Robinson, who is expected to go on season-ending IR, the 49ers face tough decisions ahead.
The performance of the offensive line is crucial, and the potential absence of Trent Williams could severely impact the team's ability to manage the game effectively.
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