Nasal vaccination recruits IgA-secreting plasma cells to defined nasal glandular acinar structures and turbinates, originating from the nasal-associated lymphoid tissues (NALTs), impacting vaccine design and upper airway allergy treatment.
The germinal centre response in the nasal-associated lymphoid tissues (NALTs) following nasal vaccination is facilitated by interactions between pre-expanded antigen-specific T cells and cognate B cells in interfollicular regions, highlighting the importance of T cell involvement in the immune response.
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