The article discusses how in female mammals, one of the two X chromosomes undergoes random inactivation, leading to varying degrees of cellular mosaicism. This random process can create a balance between expressing the maternal or paternal X chromosome, affecting genetic and epigenetic diversity and potentially influencing female health outcomes. The study conducted on mice aimed to examine whether skewing towards the maternal X chromosome impacts organ functions in middle-aged females, shedding light on age-related health variations caused by X chromosome dynamics.
In female mammals, one X chromosome is randomly inactivated post-embryonic development, creating potential for cellular mosaicism that may influence health outcomes.
The skew towards either the maternal or paternal X chromosome can affect the function and health of aging female individuals.
Our research indicates that skew towards the maternal X chromosome could impair organ functions in middle-aged female mice compared to those with X mosaicism.
This study suggests that understanding X chromosome inactivation and its consequences can help address age-related health variations in female mammals.
Collection
[
|
...
]