This study provides new insights into how lipid metabolism affects CD8+ T-cell functionality in the tumor microenvironment, suggesting therapeutic targets for improving immunotherapy responses.
Zhang and his team discovered that intratumoral CD8+ T-cells exhibit lower phospholipid levels and decreased PLPP1 expression, altering their survival and efficacy against tumors.
The deletion of PLPP1 in CD8+ T-cells resulted in impaired antitumor immunity and increased ferroptosis, highlighting the metabolic vulnerabilities of these immune cells in tumors.
PD-1 signaling is impacted by lipid metabolic pathways, revealing potential strategies to enhance checkpoint blockade therapy effectiveness against cancer.
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