"The majority of amyloid is still coming from neurons, but there is still a significant portion of amyloid that is coming from the oligodendrocytes, about 30 percent. This identifies oligodendrocytes as a significant contributor to amyloid in the brain" said Vassar.
The study reveals that oligodendrocytes, non-neuron brain cells, contribute to about one-third of amyloid plaque formation, a crucial finding for Alzheimer's research.
Previous research found that not all amyloid is produced by neurons, prompting this extensive study on oligodendrocytes to understand their role better.
...this discovery challenges the traditional views on Alzheimer's disease pathology and holds potential for the development of new therapies targeting plaque formation.
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