Researchers identified genetic variants that may predict mosaic loss of chromosome X (mLOX), impacting blood cell abnormalities and cancer risk. They found 56 common variants near autoimmune and cancer-related genes influencing mLOX development, along with rare variants in FBXO10 doubling mLOX risk.
In women with mLOX, certain inherited genetic variants on the X chromosome were observed more frequently on the retained X chromosome. These variants may indicate a growth advantage, elevating the risk of blood cancer.
A study of nearly 900,000 women revealed associations between mLOX and over 1,200 diseases, notably leukemia and pneumonia susceptibility. Future research aims to explore mLOX interactions with genetic variations and age-related changes.
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